HIV-1 capsids from B27/B57+ elite controllers escape Mx2 but are targeted by TRIM5α, leading to the induction of an antiviral state

Natacha Merindol; Mohamed El-Far; Mohamed Sylla; Nasser Masroori; Caroline Dufour; Jia-xin Li; Pearl Cherry; Mélodie B. Plourde; Cécile Tremblay; Lionel Berthoux

doi:10.1371/journal.ppat.1007398

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Open Access

Peer-reviewed

Research Article

HIV-1 capsids from B27/B57⁺ elite controllers escape Mx2 but are targeted by TRIM5α, leading to the induction of an antiviral state

Natacha Merindol,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Laboratory of antiviral immunity, Department of medical biology, Université du Québec à Trois-Rivières, Trois-Rivières, Quebec, Canada
⨯
Mohamed El-Far,

Roles Investigation, Writing – review & editing

Affiliation Department of microbiology, infectiology and immunology, Centre de Recherche du Centre Hospitalier de l’Université de Montréal, Montréal, Canada
⨯
Mohamed Sylla,

Roles Investigation

Affiliation Department of microbiology, infectiology and immunology, Centre de Recherche du Centre Hospitalier de l’Université de Montréal, Montréal, Canada
⨯
Nasser Masroori,

Roles Resources

Affiliation Laboratory of antiviral immunity, Department of medical biology, Université du Québec à Trois-Rivières, Trois-Rivières, Quebec, Canada
⨯
Caroline Dufour,

Roles Resources

Affiliation Laboratory of antiviral immunity, Department of medical biology, Université du Québec à Trois-Rivières, Trois-Rivières, Quebec, Canada
⨯
Jia-xin Li,

Roles Resources

Affiliation Laboratory of antiviral immunity, Department of medical biology, Université du Québec à Trois-Rivières, Trois-Rivières, Quebec, Canada
⨯
Pearl Cherry,

Roles Resources

Affiliation Laboratory of antiviral immunity, Department of medical biology, Université du Québec à Trois-Rivières, Trois-Rivières, Quebec, Canada

http://orcid.org/0000-0002-3984-4839

⨯
Mélodie B. Plourde,

Roles Methodology, Resources, Writing – review & editing

Affiliation Laboratory of antiviral immunity, Department of medical biology, Université du Québec à Trois-Rivières, Trois-Rivières, Quebec, Canada
⨯
Cécile Tremblay,

Roles Funding acquisition, Resources

Affiliation Department of microbiology, infectiology and immunology, Centre de Recherche du Centre Hospitalier de l’Université de Montréal, Montréal, Canada
⨯
Lionel Berthoux

Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: berthoux@uqtr.ca

Affiliation Laboratory of antiviral immunity, Department of medical biology, Université du Québec à Trois-Rivières, Trois-Rivières, Quebec, Canada

http://orcid.org/0000-0002-7776-5058

⨯

HIV-1 capsids from B27/B57⁺ elite controllers escape Mx2 but are targeted by TRIM5α, leading to the induction of an antiviral state

Natacha Merindol,
Mohamed El-Far,
Mohamed Sylla,
Nasser Masroori,
Caroline Dufour,
Jia-xin Li,
Pearl Cherry,
Mélodie B. Plourde,
Cécile Tremblay,
Lionel Berthoux

Published: November 12, 2018
https://doi.org/10.1371/journal.ppat.1007398

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