Alteration of Flt3-Ligand-dependent de novo generation of conventional dendritic cells during influenza infection contributes to respiratory bacterial superinfection

Ranin Beshara; Valentin Sencio; Daphnée Soulard; Adeline Barthélémy; Josette Fontaine; Thibault Pinteau; Lucie Deruyter; Mohamad Bachar Ismail; Christophe Paget; Jean-Claude Sirard; François Trottein; Christelle Faveeuw

doi:10.1371/journal.ppat.1007360

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Peer-reviewed

Research Article

Alteration of Flt3-Ligand-dependent de novo generation of conventional dendritic cells during influenza infection contributes to respiratory bacterial superinfection

Ranin Beshara,

Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Validation, Visualization, Writing – review & editing

Affiliations Univ. Lille, U1019 - UMR 8204 - CIIL - Centre d'Infection et d'Immunité de Lille, Lille, France, Centre National de la Recherche Scientifique, UMR 8204, Lille, France, Institut National de la Santé et de la Recherche Médicale U1019, Lille, France, Centre Hospitalier Universitaire de Lille, Lille, France, Institut Pasteur de Lille, Lille, France, Laboratoire Microbiologie Santé et Environnement (LMSE), Ecole Doctorale des Sciences et de Technologie, Faculté de Santé Publique, Université Libanaise, Tripoli, Lebanon
⨯
Valentin Sencio,

Roles Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

Affiliations Univ. Lille, U1019 - UMR 8204 - CIIL - Centre d'Infection et d'Immunité de Lille, Lille, France, Centre National de la Recherche Scientifique, UMR 8204, Lille, France, Institut National de la Santé et de la Recherche Médicale U1019, Lille, France, Centre Hospitalier Universitaire de Lille, Lille, France, Institut Pasteur de Lille, Lille, France

http://orcid.org/0000-0002-6379-4317

⨯
Daphnée Soulard,

Roles Investigation, Methodology, Validation

Affiliations Univ. Lille, U1019 - UMR 8204 - CIIL - Centre d'Infection et d'Immunité de Lille, Lille, France, Centre National de la Recherche Scientifique, UMR 8204, Lille, France, Institut National de la Santé et de la Recherche Médicale U1019, Lille, France, Centre Hospitalier Universitaire de Lille, Lille, France, Institut Pasteur de Lille, Lille, France
⨯
Adeline Barthélémy,

Roles Investigation, Methodology, Writing – review & editing

Affiliations Univ. Lille, U1019 - UMR 8204 - CIIL - Centre d'Infection et d'Immunité de Lille, Lille, France, Centre National de la Recherche Scientifique, UMR 8204, Lille, France, Institut National de la Santé et de la Recherche Médicale U1019, Lille, France, Centre Hospitalier Universitaire de Lille, Lille, France, Institut Pasteur de Lille, Lille, France

http://orcid.org/0000-0001-5365-1163

⨯
Josette Fontaine,

Roles Investigation, Methodology, Validation

Affiliations Univ. Lille, U1019 - UMR 8204 - CIIL - Centre d'Infection et d'Immunité de Lille, Lille, France, Centre National de la Recherche Scientifique, UMR 8204, Lille, France, Institut National de la Santé et de la Recherche Médicale U1019, Lille, France, Centre Hospitalier Universitaire de Lille, Lille, France, Institut Pasteur de Lille, Lille, France
⨯
Thibault Pinteau,

Roles Investigation, Methodology, Validation

Affiliations Univ. Lille, U1019 - UMR 8204 - CIIL - Centre d'Infection et d'Immunité de Lille, Lille, France, Centre National de la Recherche Scientifique, UMR 8204, Lille, France, Institut National de la Santé et de la Recherche Médicale U1019, Lille, France, Centre Hospitalier Universitaire de Lille, Lille, France, Institut Pasteur de Lille, Lille, France
⨯
Lucie Deruyter,

Roles Investigation, Methodology, Validation

Affiliations Univ. Lille, U1019 - UMR 8204 - CIIL - Centre d'Infection et d'Immunité de Lille, Lille, France, Centre National de la Recherche Scientifique, UMR 8204, Lille, France, Institut National de la Santé et de la Recherche Médicale U1019, Lille, France, Centre Hospitalier Universitaire de Lille, Lille, France, Institut Pasteur de Lille, Lille, France
⨯
Mohamad Bachar Ismail,

Roles Supervision, Writing – review & editing

Affiliation Laboratoire Microbiologie Santé et Environnement (LMSE), Ecole Doctorale des Sciences et de Technologie, Faculté de Santé Publique, Université Libanaise, Tripoli, Lebanon

http://orcid.org/0000-0003-4347-1913

⨯
Christophe Paget,

Roles Conceptualization, Investigation, Writing – review & editing

Current address: Univ. Tours, Inserm, Centre d'Etude des Pathologies Respiratoires (CEPR), UMR 1100, Tours, France

Affiliations Univ. Lille, U1019 - UMR 8204 - CIIL - Centre d'Infection et d'Immunité de Lille, Lille, France, Centre National de la Recherche Scientifique, UMR 8204, Lille, France, Institut National de la Santé et de la Recherche Médicale U1019, Lille, France, Centre Hospitalier Universitaire de Lille, Lille, France, Institut Pasteur de Lille, Lille, France
⨯
Jean-Claude Sirard,

Roles Conceptualization, Investigation, Methodology, Writing – review & editing

Affiliations Univ. Lille, U1019 - UMR 8204 - CIIL - Centre d'Infection et d'Immunité de Lille, Lille, France, Centre National de la Recherche Scientifique, UMR 8204, Lille, France, Institut National de la Santé et de la Recherche Médicale U1019, Lille, France, Centre Hospitalier Universitaire de Lille, Lille, France, Institut Pasteur de Lille, Lille, France

http://orcid.org/0000-0001-9854-4652

⨯
François Trottein,

Roles Conceptualization, Funding acquisition, Resources, Writing – review & editing

Affiliations Univ. Lille, U1019 - UMR 8204 - CIIL - Centre d'Infection et d'Immunité de Lille, Lille, France, Centre National de la Recherche Scientifique, UMR 8204, Lille, France, Institut National de la Santé et de la Recherche Médicale U1019, Lille, France, Centre Hospitalier Universitaire de Lille, Lille, France, Institut Pasteur de Lille, Lille, France
⨯
Christelle Faveeuw

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: christelle.faveeuw@inserm.fr

Affiliations Univ. Lille, U1019 - UMR 8204 - CIIL - Centre d'Infection et d'Immunité de Lille, Lille, France, Centre National de la Recherche Scientifique, UMR 8204, Lille, France, Institut National de la Santé et de la Recherche Médicale U1019, Lille, France, Centre Hospitalier Universitaire de Lille, Lille, France, Institut Pasteur de Lille, Lille, France

http://orcid.org/0000-0002-8373-3992

⨯

Alteration of Flt3-Ligand-dependent de novo generation of conventional dendritic cells during influenza infection contributes to respiratory bacterial superinfection

Ranin Beshara,
Valentin Sencio,
Daphnée Soulard,
Adeline Barthélémy,
Josette Fontaine,
Thibault Pinteau,
Lucie Deruyter,
Mohamad Bachar Ismail,
Christophe Paget,
Jean-Claude Sirard

Published: October 29, 2018
https://doi.org/10.1371/journal.ppat.1007360

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