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Open Access
Peer-reviewed
Research Article
Critical role for cholesterol in Lassa fever virus entry identified by a novel small molecule inhibitor targeting the viral receptor LAMP1
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May Kwang-Mei Wang,
Roles Conceptualization, Funding acquisition, Investigation, Methodology, Writing – original draft, Writing – review & editing
Affiliations Division of Hematology, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, United States of America
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Tao Ren,
Roles Conceptualization, Investigation, Methodology
Current address: CAS Institute of Technology Innovation, Hefei, China
Affiliation Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, United States of America
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Hu Liu,
Roles Investigation, Methodology, Writing – original draft
Affiliation Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, United States of America
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Sun-Young Lim,
Roles Investigation, Methodology
Affiliation Division of Hematology, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America
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Kyungae Lee,
Roles Investigation, Methodology
Current address: Broad Institute, Cambridge, Massachusetts, United States of America
Affiliation Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, United States of America
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Anna Honko,
Roles Investigation, Methodology
Current address: Vaccine Research Center, NIAID/NIH, Bethesda, Maryland, United States of America
Affiliation United States Army Medical Research institute of Infectious Disease, Fort Detrick, Maryland, United States of America
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Huanying Zhou,
Roles Investigation
Affiliation NIAID/NIH Integrated Research Facility, Fort Detrick, Maryland, United States of America
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Julie Dyall,
Roles Data curation
Affiliation NIAID/NIH Integrated Research Facility, Fort Detrick, Maryland, United States of America
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Lisa Hensley,
Roles Investigation, Methodology
Affiliation NIAID/NIH Integrated Research Facility, Fort Detrick, Maryland, United States of America
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Ashley K. Gartin,
Roles Methodology
Affiliations Division of Hematology, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, United States of America
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James M. Cunningham
Roles Conceptualization, Funding acquisition, Methodology, Writing – original draft, Writing – review & editing
* E-mail: jcunningham@bwh.harvard.edu
Affiliations Division of Hematology, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, United States of America
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Critical role for cholesterol in Lassa fever virus entry identified by a novel small molecule inhibitor targeting the viral receptor LAMP1
- May Kwang-Mei Wang,
- Tao Ren,
- Hu Liu,
- Sun-Young Lim,
- Kyungae Lee,
- Anna Honko,
- Huanying Zhou,
- Julie Dyall,
- Lisa Hensley,
- Ashley K. Gartin
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- Published: September 28, 2018
- https://doi.org/10.1371/journal.ppat.1007322