Promyelocytic leukemia (PML) nuclear bodies (NBs) induce latent/quiescent HSV-1 genomes chromatinization through a PML NB/Histone H3.3/H3.3 Chaperone Axis

Camille Cohen; Armelle Corpet; Simon Roubille; Mohamed Ali Maroui; Nolwenn Poccardi; Antoine Rousseau; Constance Kleijwegt; Olivier Binda; Pascale Texier; Nancy Sawtell; Marc Labetoulle; Patrick Lomonte

doi:10.1371/journal.ppat.1007313

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Peer-reviewed

Research Article

Promyelocytic leukemia (PML) nuclear bodies (NBs) induce latent/quiescent HSV-1 genomes chromatinization through a PML NB/Histone H3.3/H3.3 Chaperone Axis

Camille Cohen,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Univ Lyon, Université Claude Bernard Lyon 1, CNRS UMR 5310, INSERM U 1217, LabEx DEVweCAN, Institut NeuroMyoGène (INMG), team Chromatin Assembly, Nuclear Domains, Virus, Lyon, France
⨯
Armelle Corpet,

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Writing – original draft

Affiliation Univ Lyon, Université Claude Bernard Lyon 1, CNRS UMR 5310, INSERM U 1217, LabEx DEVweCAN, Institut NeuroMyoGène (INMG), team Chromatin Assembly, Nuclear Domains, Virus, Lyon, France
⨯
Simon Roubille,

Roles Investigation

Affiliation Univ Lyon, Université Claude Bernard Lyon 1, CNRS UMR 5310, INSERM U 1217, LabEx DEVweCAN, Institut NeuroMyoGène (INMG), team Chromatin Assembly, Nuclear Domains, Virus, Lyon, France
⨯
Mohamed Ali Maroui,

Roles Investigation

Affiliation Univ Lyon, Université Claude Bernard Lyon 1, CNRS UMR 5310, INSERM U 1217, LabEx DEVweCAN, Institut NeuroMyoGène (INMG), team Chromatin Assembly, Nuclear Domains, Virus, Lyon, France
⨯
Nolwenn Poccardi,

Roles Investigation

Affiliation Institut de Biologie Intégrative de la Cellule (I2BC), Département de Virologie, Gif-sur-Yvette, France
⨯
Antoine Rousseau,

Roles Investigation

Current address: Université Paris Sud, UMR 1184, Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Infectious diseases models for innovative therapies (IDMIT), Immunologie des Infections Virales et des Maladies Auto-immunes (IMVA), France

Affiliations Institut de Biologie Intégrative de la Cellule (I2BC), Département de Virologie, Gif-sur-Yvette, France, Université Paris Sud, Centre Hospitalier Universitaire de Bicêtre, Service d'Ophthalmologie, Le Kremlin-Bicêtre, France
⨯
Constance Kleijwegt,

Roles Investigation

Affiliation Univ Lyon, Université Claude Bernard Lyon 1, CNRS UMR 5310, INSERM U 1217, LabEx DEVweCAN, Institut NeuroMyoGène (INMG), team Chromatin Assembly, Nuclear Domains, Virus, Lyon, France
⨯
Olivier Binda,

Roles Investigation

Affiliation Univ Lyon, Université Claude Bernard Lyon 1, CNRS UMR 5310, INSERM U 1217, LabEx DEVweCAN, Institut NeuroMyoGène (INMG), team Chromatin Assembly, Nuclear Domains, Virus, Lyon, France
⨯
Pascale Texier,

Roles Investigation

Affiliation Univ Lyon, Université Claude Bernard Lyon 1, CNRS UMR 5310, INSERM U 1217, LabEx DEVweCAN, Institut NeuroMyoGène (INMG), team Chromatin Assembly, Nuclear Domains, Virus, Lyon, France
⨯
Nancy Sawtell,

Roles Investigation

Affiliation Division of Infectious Diseases, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America
⨯
Marc Labetoulle,

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Supervision, Validation, Visualization

Current address: Université Paris Sud, UMR 1184, Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Infectious diseases models for innovative therapies (IDMIT), Immunologie des Infections Virales et des Maladies Auto-immunes (IMVA), France

Affiliations Institut de Biologie Intégrative de la Cellule (I2BC), Département de Virologie, Gif-sur-Yvette, France, Université Paris Sud, Centre Hospitalier Universitaire de Bicêtre, Service d'Ophthalmologie, Le Kremlin-Bicêtre, France
⨯
Patrick Lomonte

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: patrick.lomonte@univ-lyon1.fr

Affiliation Univ Lyon, Université Claude Bernard Lyon 1, CNRS UMR 5310, INSERM U 1217, LabEx DEVweCAN, Institut NeuroMyoGène (INMG), team Chromatin Assembly, Nuclear Domains, Virus, Lyon, France

http://orcid.org/0000-0001-9248-648X

⨯

Promyelocytic leukemia (PML) nuclear bodies (NBs) induce latent/quiescent HSV-1 genomes chromatinization through a PML NB/Histone H3.3/H3.3 Chaperone Axis

Camille Cohen,
Armelle Corpet,
Simon Roubille,
Mohamed Ali Maroui,
Nolwenn Poccardi,
Antoine Rousseau,
Constance Kleijwegt,
Olivier Binda,
Pascale Texier,
Nancy Sawtell

Published: September 20, 2018
https://doi.org/10.1371/journal.ppat.1007313
See the preprint

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