Active-site mTOR inhibitors augment HSV1-dICP0 infection in cancer cells via dysregulated eIF4E/4E-BP axis

• Chadi Zakaria,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

  Affiliation Goodman Cancer Centre, Department of Biochemistry, McGill University, Montreal, Canada

  ⨯
• Polen Sean,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft

  Affiliation Goodman Cancer Centre, Department of Biochemistry, McGill University, Montreal, Canada

  ⨯
• Huy-Dung Hoang,

  Roles Data curation, Formal analysis, Validation

  Affiliation Children's Hospital of Eastern Ontario Research Institute, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada

  ⨯
• Louis-Phillipe Leroux,

  Roles Conceptualization, Data curation, Formal analysis, Validation

  Affiliation INRS Institut Armand-Frappier Research Centre, Laval, Quebec, Canada

  http://orcid.org/0000-0002-9736-1827

  ⨯
• Margaret Watson,

  Roles Data curation, Formal analysis, Validation

  Affiliation Children's Hospital of Eastern Ontario Research Institute, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada

  ⨯
• Samuel Tekeste Workenhe,

  Roles Resources

  Affiliation Department of Pathology and Molecular Medicine, MG DeGroote Institute for Infectious Disease, McMaster University, Hamilton, Ontario, Canada

  ⨯
• Jaclyn Hearnden,

  Roles Conceptualization, Data curation, Formal analysis, Validation

  Affiliation Goodman Cancer Centre, Department of Biochemistry, McGill University, Montreal, Canada

  ⨯
• Dana Pearl,

  Roles Data curation, Formal analysis

  Affiliation Goodman Cancer Centre, Department of Biochemistry, McGill University, Montreal, Canada

  ⨯
• Vinh Tai Truong,

  Roles Data curation, Formal analysis

  Affiliation Goodman Cancer Centre, Department of Biochemistry, McGill University, Montreal, Canada

  ⨯
• Nathaniel Robichaud,

  Roles Data curation, Formal analysis

  Affiliation Goodman Cancer Centre, Department of Biochemistry, McGill University, Montreal, Canada

  http://orcid.org/0000-0002-7653-0767

  ⨯
• Akiko Yanagiya,

  Roles Data curation, Formal analysis

  Affiliation Goodman Cancer Centre, Department of Biochemistry, McGill University, Montreal, Canada

  ⨯
• Soroush Tahmasebi,

  Roles Data curation, Formal analysis

  Affiliation Goodman Cancer Centre, Department of Biochemistry, McGill University, Montreal, Canada

  ⨯
• Seyed Mehdi Jafarnejad,

  Roles Data curation, Formal analysis

  Affiliation Goodman Cancer Centre, Department of Biochemistry, McGill University, Montreal, Canada

  ⨯
• Jian-Jun Jia,

  Roles Data curation, Formal analysis

  Affiliation Children's Hospital of Eastern Ontario Research Institute, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada

  ⨯
• Adrian Pelin,

  Roles Data curation, Formal analysis

  Affiliation Center for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada

  ⨯
• Jean-Simon Diallo,

  Roles Data curation, Formal analysis, Funding acquisition

  Affiliation Center for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada

  http://orcid.org/0000-0002-4862-2795

  ⨯
• Fabrice Le Boeuf,

  Roles Conceptualization, Data curation, Formal analysis, Methodology

  Affiliation Center for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada

  http://orcid.org/0000-0003-3706-2304

  ⨯
• John Cameron Bell,

  Roles Resources

  Affiliation Center for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada

  ⨯
• Karen Louise Mossman,

  Roles Resources

  Affiliation Department of Pathology and Molecular Medicine, MG DeGroote Institute for Infectious Disease, McMaster University, Hamilton, Ontario, Canada

  http://orcid.org/0000-0002-1725-5873

  ⨯
• Tyson Ernst Graber,

  Roles Data curation, Formal analysis, Visualization, Writing – review & editing

  Affiliation Children's Hospital of Eastern Ontario Research Institute, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada

  http://orcid.org/0000-0002-5337-3404

  ⨯
• Maritza Jaramillo,

  Roles Conceptualization, Data curation, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  Affiliation INRS Institut Armand-Frappier Research Centre, Laval, Quebec, Canada

  ⨯
• Nahum Sonenberg ,

  Roles Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: nahum.sonenberg@mcgill.ca (NS); tommy@arc.cheo.ca (TA)

  Affiliation Goodman Cancer Centre, Department of Biochemistry, McGill University, Montreal, Canada

  ⨯
•  [ ... ],
• Tommy Alain

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: nahum.sonenberg@mcgill.ca (NS); tommy@arc.cheo.ca (TA)

  Affiliation Children's Hospital of Eastern Ontario Research Institute, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada

  http://orcid.org/0000-0002-0396-9138

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