Type I IFN signaling blockade by a PASylated antagonist during chronic SIV infection suppresses specific inflammatory pathways but does not alter T cell activation or virus replication

• Krystelle Nganou-Makamdop,

  Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Visualization, Writing – original draft, Writing – review & editing

  Current address: Institute of Clinical and Molecular Virology, University Hospital Erlangen, Erlangen, Germany.

  Affiliation Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

  ⨯
• James M. Billingsley,

  Roles Formal analysis, Software, Writing – original draft, Writing – review & editing

  Affiliation Division of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate Research Center, Atlanta, Georgia, United States of America

  ⨯
• Zachary Yaffe,

  Roles Formal analysis, Investigation, Methodology

  Affiliation Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

  http://orcid.org/0000-0003-2998-0172

  ⨯
• Gregory O’Connor,

  Roles Formal analysis, Investigation, Methodology

  Affiliation Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

  http://orcid.org/0000-0001-5706-3959

  ⨯
• Gregory K. Tharp,

  Roles Formal analysis, Resources, Software

  Affiliation Division of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate Research Center, Atlanta, Georgia, United States of America

  ⨯
• Amy Ransier,

  Roles Methodology

  Affiliation Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

  ⨯
• Farida Laboune,

  Roles Methodology

  Affiliation Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

  ⨯
• Rodrigo Matus-Nicodemos,

  Roles Methodology

  Affiliation Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

  ⨯
• Andrea Lerner,

  Roles Methodology

  Affiliation Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

  http://orcid.org/0000-0003-2358-796X

  ⨯
• Lavina Gharu,

  Roles Methodology

  Affiliation Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

  ⨯
• Jennifer M. Robertson,

  Roles Formal analysis, Methodology

  Affiliation Department of Surgery and Emory Transplant Center, Emory University School of Medicine and Emory Healthcare, Atlanta, GA

  ⨯
• Mandy L. Ford,

  Roles Formal analysis, Methodology

  Affiliation Department of Surgery and Emory Transplant Center, Emory University School of Medicine and Emory Healthcare, Atlanta, GA

  ⨯
• Martin Schlapschy,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliation Lehrstuhl für Biologische Chemie, Technische Universität München, Freising (Weihenstephan), Germany

  ⨯
• Nadine Kuhn,

  Roles Methodology

  Affiliation Lehrstuhl für Biologische Chemie, Technische Universität München, Freising (Weihenstephan), Germany

  http://orcid.org/0000-0001-5625-1990

  ⨯
• Alexandra Lensch,

  Roles Methodology

  Affiliation Lehrstuhl für Biologische Chemie, Technische Universität München, Freising (Weihenstephan), Germany

  ⨯
• Jeffrey Lifson,

  Roles Formal analysis, Funding acquisition, Investigation, Methodology

  Affiliation AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America

  ⨯
• Martha Nason,

  Roles Formal analysis, Methodology

  Affiliation Biostatistics Research Branch, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

  ⨯
• Arne Skerra,

  Roles Formal analysis, Investigation, Methodology, Resources, Supervision, Writing – review & editing

  Affiliations Lehrstuhl für Biologische Chemie, Technische Universität München, Freising (Weihenstephan), Germany, XL-protein GmbH, Freising, Germany

  http://orcid.org/0000-0002-5717-498X

  ⨯
• Gideon Schreiber,

  Roles Conceptualization, Investigation, Resources, Supervision, Writing – review & editing

  Affiliation Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel

  ⨯
• Steven E. Bosinger,

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Supervision, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Division of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate Research Center, Atlanta, Georgia, United States of America, Department of Pathology & Laboratory Medicine, Emory University, Atlanta, Georgia, United States of America

  http://orcid.org/0000-0002-2116-5061

  ⨯
•  [ ... ],
• Daniel C. Douek

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: ddouek@mail.nih.gov

  Affiliation Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

  http://orcid.org/0000-0001-5575-8634

  ⨯
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