Enzymatic chokepoints and synergistic drug targets in the sterol biosynthesis pathway of Naegleria fowleri

• Wenxu Zhou ,

  Contributed equally to this work with: Wenxu Zhou, Anjan Debnath

  Roles Formal analysis, Investigation, Methodology

  Affiliation Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas, United States of America

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• Anjan Debnath ,

  Contributed equally to this work with: Wenxu Zhou, Anjan Debnath

  Roles Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Writing – review & editing

  Affiliation Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, United States of America

  http://orcid.org/0000-0001-9294-3927

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• Gareth Jennings,

  Roles Investigation, Methodology, Visualization

  Affiliation Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, United States of America

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• Hye Jee Hahn,

  Roles Investigation, Methodology

  Affiliation Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, United States of America

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• Boden H. Vanderloop,

  Roles Investigation

  Affiliation Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas, United States of America

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• Minu Chaudhuri,

  Roles Investigation, Methodology

  Affiliation Department of Microbiology and Immunology, Meharry Medical College, Nashville, Tennessee, United States of America

  http://orcid.org/0000-0001-7626-1280

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• W. David Nes,

  Roles Data curation, Funding acquisition, Resources, Writing – review & editing

  Affiliation Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas, United States of America

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• Larissa M. Podust

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: lpodust@ucsd.edu

  Affiliation Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, United States of America

  http://orcid.org/0000-0002-8537-8760

  ⨯