Interferon-beta expression and type I interferon receptor signaling of hepatocytes prevent hepatic necrosis and virus dissemination in Coxsackievirus B3-infected mice

• Wolfgang Koestner ,

  Contributed equally to this work with: Wolfgang Koestner, Julia Spanier, Tanja Klause

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Validation, Visualization, Writing – original draft

  Affiliations Institute for Radiology, Hannover Medical School, Hannover, Germany, Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research, Braunschweig, and the Hannover Medical School, Hannover, Germany

  http://orcid.org/0000-0002-3798-2277

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• Julia Spanier ,

  Contributed equally to this work with: Wolfgang Koestner, Julia Spanier, Tanja Klause

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research, Braunschweig, and the Hannover Medical School, Hannover, Germany

  http://orcid.org/0000-0002-8797-3563

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• Tanja Klause ,

  Contributed equally to this work with: Wolfgang Koestner, Julia Spanier, Tanja Klause

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Validation, Visualization, Writing – original draft

  Affiliation Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research, Braunschweig, and the Hannover Medical School, Hannover, Germany

  ⨯
• Pia-K. Tegtmeyer,

  Roles Data curation, Formal analysis, Investigation, Validation

  Affiliation Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research, Braunschweig, and the Hannover Medical School, Hannover, Germany

  http://orcid.org/0000-0001-6425-3208

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• Jennifer Becker,

  Roles Data curation, Formal analysis, Investigation, Validation

  Affiliation Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research, Braunschweig, and the Hannover Medical School, Hannover, Germany

  ⨯
• Vanessa Herder,

  Roles Data curation, Formal analysis, Investigation, Validation, Visualization, Writing – original draft

  Affiliation Department of Pathology, University of Veterinary Medicine Hannover, Hannover, Germany

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• Katharina Borst,

  Roles Data curation, Investigation, Validation, Writing – original draft

  Affiliation Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research, Braunschweig, and the Hannover Medical School, Hannover, Germany

  ⨯
• Daniel Todt,

  Roles Data curation, Formal analysis, Methodology, Software

  Affiliation Department of Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany

  http://orcid.org/0000-0002-3564-1014

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• Stefan Lienenklaus,

  Roles Data curation, Investigation, Resources, Validation

  Affiliations Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research, Braunschweig, and the Hannover Medical School, Hannover, Germany, Institute for Laboratory Animal Science and Central Animal Facility, Hannover Medical School, Hannover, Germany

  ⨯
• Ingo Gerhauser,

  Roles Investigation, Visualization

  Affiliation Department of Pathology, University of Veterinary Medicine Hannover, Hannover, Germany

  ⨯
• Claudia N. Detje,

  Roles Conceptualization, Data curation, Formal analysis, Validation

  Affiliation Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research, Braunschweig, and the Hannover Medical School, Hannover, Germany

  ⨯
• Robert Geffers,

  Roles Data curation, Methodology

  Affiliation Helmholtz Centre for Infection Research, Genome Analytics Research Group, Braunschweig, Germany

  ⨯
• Martijn A. Langereis,

  Roles Resources

  Affiliation Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands

  ⨯
• Florian W. R. Vondran,

  Roles Resources

  Affiliation ReMediES, Department of General, Visceral and Transplantation Surgery, Hannover Medical School, and German Centre for Infection Research, Hannover-Braunschweig, Germany

  http://orcid.org/0000-0001-8355-5017

  ⨯
• Qinggong Yuan,

  Roles Resources

  Affiliation Institute for Cell and Gene Therapy, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research, Braunschweig, and the Hannover Medical School, Hannover, Germany

  ⨯
• Frank J. M. van Kuppeveld,

  Roles Resources

  Affiliation Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands

  ⨯
• Michael Ott,

  Roles Resources, Writing – original draft

  Affiliation Institute for Cell and Gene Therapy, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research, Braunschweig, and the Hannover Medical School, Hannover, Germany

  ⨯
• Peter Staeheli,

  Roles Resources, Writing – review & editing

  Affiliations Institute for Virology, Medical Center University of Freiburg, Freiburg, Germany, Faculty of Medicine, University of Freiburg, Freiburg, Germany

  ⨯
• Eike Steinmann,

  Roles Methodology, Resources, Writing – review & editing

  Affiliation Department of Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany

  ⨯
• Wolfgang Baumgärtner,

  Roles Resources, Writing – original draft

  Affiliation Department of Pathology, University of Veterinary Medicine Hannover, Hannover, Germany

  ⨯
• Frank Wacker,

  Roles Funding acquisition, Writing – original draft

  Affiliation Institute for Radiology, Hannover Medical School, Hannover, Germany

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•  [ ... ],
• Ulrich Kalinke

  Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

  * E-mail: ulrich.kalinke@twincore.de

  Affiliation Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research, Braunschweig, and the Hannover Medical School, Hannover, Germany

  http://orcid.org/0000-0003-0503-9564

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