Epstein-Barr virus activates F-box protein FBXO2 to limit viral infectivity by targeting glycoprotein B for degradation

Hao-Jiong Zhang; Jinxiu Tian; Xue-Kang Qi; Tong Xiang; Gui-Ping He; Hua Zhang; Xibao Yu; Xiao Zhang; Bingchun Zhao; Qi-Sheng Feng; Ming-Yuan Chen; Mu-Sheng Zeng; Yi-Xin Zeng; Lin Feng

doi:10.1371/journal.ppat.1007208

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Open Access

Peer-reviewed

Research Article

Epstein-Barr virus activates F-box protein FBXO2 to limit viral infectivity by targeting glycoprotein B for degradation

Hao-Jiong Zhang ,

Contributed equally to this work with: Hao-Jiong Zhang, Jinxiu Tian, Xue-Kang Qi

Roles Data curation, Investigation, Validation, Writing – original draft

Affiliation Department of Experimental Research, Sun Yat-sen University Cancer Center, State Key Laboratory Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
⨯
Jinxiu Tian ,

Contributed equally to this work with: Hao-Jiong Zhang, Jinxiu Tian, Xue-Kang Qi

Roles Data curation, Formal analysis, Methodology, Validation

Affiliation Department of Experimental Research, Sun Yat-sen University Cancer Center, State Key Laboratory Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China

http://orcid.org/0000-0001-9879-3050

⨯
Xue-Kang Qi ,

Contributed equally to this work with: Hao-Jiong Zhang, Jinxiu Tian, Xue-Kang Qi

Roles Data curation, Methodology, Resources

Affiliation Department of Experimental Research, Sun Yat-sen University Cancer Center, State Key Laboratory Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
⨯
Tong Xiang,

Roles Investigation, Resources, Software

Affiliation Department of Experimental Research, Sun Yat-sen University Cancer Center, State Key Laboratory Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
⨯
Gui-Ping He,

Roles Project administration, Resources

Affiliation Department of Experimental Research, Sun Yat-sen University Cancer Center, State Key Laboratory Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
⨯
Hua Zhang,

Roles Methodology

Affiliation Department of Experimental Research, Sun Yat-sen University Cancer Center, State Key Laboratory Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
⨯
Xibao Yu,

Roles Resources

Affiliation Department of Experimental Research, Sun Yat-sen University Cancer Center, State Key Laboratory Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
⨯
Xiao Zhang,

Roles Visualization

Affiliation Department of Experimental Research, Sun Yat-sen University Cancer Center, State Key Laboratory Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
⨯
Bingchun Zhao,

Roles Visualization

Affiliation Department of Experimental Research, Sun Yat-sen University Cancer Center, State Key Laboratory Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
⨯
Qi-Sheng Feng,

Roles Project administration

Affiliation Department of Experimental Research, Sun Yat-sen University Cancer Center, State Key Laboratory Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
⨯
Ming-Yuan Chen,

Roles Resources

Affiliation Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China
⨯
Mu-Sheng Zeng,

Roles Conceptualization, Resources, Supervision

Affiliation Department of Experimental Research, Sun Yat-sen University Cancer Center, State Key Laboratory Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
⨯
Yi-Xin Zeng ,

Roles Funding acquisition, Investigation, Supervision

* E-mail: zengyx@sysucc.org.cn (YXZ); fengl@sysucc.org.cn (LF)

Affiliation Department of Experimental Research, Sun Yat-sen University Cancer Center, State Key Laboratory Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
⨯
Lin Feng

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Supervision, Writing – review & editing

* E-mail: zengyx@sysucc.org.cn (YXZ); fengl@sysucc.org.cn (LF)

Affiliation Department of Experimental Research, Sun Yat-sen University Cancer Center, State Key Laboratory Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China

http://orcid.org/0000-0001-6461-5838

⨯

Epstein-Barr virus activates F-box protein FBXO2 to limit viral infectivity by targeting glycoprotein B for degradation

Hao-Jiong Zhang,
Jinxiu Tian,
Xue-Kang Qi,
Tong Xiang,
Gui-Ping He,
Hua Zhang,
Xibao Yu,
Xiao Zhang,
Bingchun Zhao,
Qi-Sheng Feng

Published: July 27, 2018
https://doi.org/10.1371/journal.ppat.1007208

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