Caspase-11-dependent pyroptosis of lung epithelial cells protects from melioidosis while caspase-1 mediates macrophage pyroptosis and production of IL-18

Jinyong Wang; Manoranjan Sahoo; Louis Lantier; Jonathan Warawa; Hector Cordero; Kelly Deobald; Fabio Re

doi:10.1371/journal.ppat.1007105

Loading metrics

Open Access

Peer-reviewed

Research Article

Caspase-11-dependent pyroptosis of lung epithelial cells protects from melioidosis while caspase-1 mediates macrophage pyroptosis and production of IL-18

Jinyong Wang ,

Roles Investigation

¶‡ These authors share first authorship on this work.

Affiliation Department of Microbiology and Immunology, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, United States of America
⨯
Manoranjan Sahoo ,

Roles Investigation

¶‡ These authors share first authorship on this work.

Affiliation Department of Microbiology and Immunology, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, United States of America

http://orcid.org/0000-0002-6734-7346

⨯
Louis Lantier,

Roles Investigation

Affiliation Department of Microbiology and Immunology, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, United States of America
⨯
Jonathan Warawa,

Roles Investigation

Affiliation Department of Microbiology and Immunology, University of Louisville, Louisville, Kentucky, United States of America
⨯
Hector Cordero,

Roles Investigation

Affiliation Department of Microbiology and Immunology, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, United States of America
⨯
Kelly Deobald,

Roles Investigation

Affiliation Department of Microbiology and Immunology, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, United States of America
⨯
Fabio Re

Roles Conceptualization, Funding acquisition, Investigation, Project administration, Supervision, Writing – original draft

* E-mail: fabio.re@rosalindfranklin.edu

Affiliation Department of Microbiology and Immunology, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, United States of America

http://orcid.org/0000-0002-1181-0717

⨯

Caspase-11-dependent pyroptosis of lung epithelial cells protects from melioidosis while caspase-1 mediates macrophage pyroptosis and production of IL-18

Jinyong Wang,
Manoranjan Sahoo,
Louis Lantier,
Jonathan Warawa,
Hector Cordero,
Kelly Deobald,
Fabio Re

Published: May 23, 2018
https://doi.org/10.1371/journal.ppat.1007105

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Melioidosis
Is the Subject Area "Melioidosis" applicable to this article?

Thanks for your feedback.
Burkholderia infection
Is the Subject Area "Burkholderia infection" applicable to this article?

Thanks for your feedback.
Epithelial cells
Is the Subject Area "Epithelial cells" applicable to this article?

Thanks for your feedback.
Macrophages
Is the Subject Area "Macrophages" applicable to this article?

Thanks for your feedback.
Bone marrow cells
Is the Subject Area "Bone marrow cells" applicable to this article?

Thanks for your feedback.
Neutrophils
Is the Subject Area "Neutrophils" applicable to this article?

Thanks for your feedback.
Inflammasomes
Is the Subject Area "Inflammasomes" applicable to this article?

Thanks for your feedback.
Mouse models
Is the Subject Area "Mouse models" applicable to this article?

Thanks for your feedback.