Hepatitis C virus NS4B induces the degradation of TRIF to inhibit TLR3-mediated interferon signaling pathway

• Yisha Liang ,

  Contributed equally to this work with: Yisha Liang, Xuezhi Cao

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliations CAS Key Laboratory of Molecular Virology and Immunology, Unit of Viral Hepatitis, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China, ShanghaiTech University, Shanghai, China, University of Chinese Academy of Sciences, Beijing, China

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• Xuezhi Cao ,

  Contributed equally to this work with: Yisha Liang, Xuezhi Cao

  Roles Conceptualization, Formal analysis, Investigation, Methodology

  Affiliation CAS Key Laboratory of Molecular Virology and Immunology, Unit of Viral Hepatitis, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China

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• Qiang Ding,

  Roles Formal analysis, Investigation, Methodology

  Affiliation CAS Key Laboratory of Molecular Virology and Immunology, Unit of Viral Hepatitis, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China

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• Yanan Zhao,

  Roles Formal analysis, Methodology

  Affiliations CAS Key Laboratory of Molecular Virology and Immunology, Unit of Viral Hepatitis, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China, University of Chinese Academy of Sciences, Beijing, China

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• Zhenliang He,

  Roles Formal analysis, Methodology

  Affiliations CAS Key Laboratory of Molecular Virology and Immunology, Unit of Viral Hepatitis, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China, University of Chinese Academy of Sciences, Beijing, China

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• Jin Zhong

  Roles Conceptualization, Funding acquisition, Investigation, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: jzhong@ips.ac.cn

  Affiliations CAS Key Laboratory of Molecular Virology and Immunology, Unit of Viral Hepatitis, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China, ShanghaiTech University, Shanghai, China, University of Chinese Academy of Sciences, Beijing, China

  http://orcid.org/0000-0002-3554-1275

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