A lipid-binding loop of botulinum neurotoxin serotypes B, DC and G is an essential feature to confer their exquisite potency

• Daniel Stern ,

  Contributed equally to this work with: Daniel Stern, Jasmin Weisemann, Brigitte Gertrud Dorner, Andreas Rummel

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  Affiliation Biological Toxins (ZBS 3), Centre for Biological Threats and Special Pathogens, Robert Koch Institute, Berlin, Germany

  http://orcid.org/0000-0001-9057-4283

  ⨯
• Jasmin Weisemann ,

  Contributed equally to this work with: Daniel Stern, Jasmin Weisemann, Brigitte Gertrud Dorner, Andreas Rummel

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – review & editing

  Affiliation Institut für Toxikologie, Medizinische Hochschule Hannover, Hannover, Germany

  ⨯
• Alexander Le Blanc,

  Roles Methodology

  Affiliation Institute for Clinical Chemistry and Pathobiochemistry, Klinikum rechts der Isar, Technische Universität München, München, Germany

  ⨯
• Laura von Berg,

  Roles Investigation

  Affiliation Biological Toxins (ZBS 3), Centre for Biological Threats and Special Pathogens, Robert Koch Institute, Berlin, Germany

  http://orcid.org/0000-0002-3360-5917

  ⨯
• Stefan Mahrhold,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation Institut für Toxikologie, Medizinische Hochschule Hannover, Hannover, Germany

  ⨯
• Janett Piesker,

  Roles Investigation

  Affiliation Advanced Light and Electron Microscopy (ZBS 4), Centre for Biological Threats and Special Pathogens, Robert Koch Institute, Berlin, Germany

  ⨯
• Michael Laue,

  Roles Investigation, Resources

  Affiliation Advanced Light and Electron Microscopy (ZBS 4), Centre for Biological Threats and Special Pathogens, Robert Koch Institute, Berlin, Germany

  http://orcid.org/0000-0002-6474-9139

  ⨯
• Peter B. Luppa,

  Roles Methodology, Resources

  Affiliation Institute for Clinical Chemistry and Pathobiochemistry, Klinikum rechts der Isar, Technische Universität München, München, Germany

  ⨯
• Martin Bernhard Dorner,

  Roles Conceptualization, Data curation, Investigation, Supervision, Writing – review & editing

  Affiliation Biological Toxins (ZBS 3), Centre for Biological Threats and Special Pathogens, Robert Koch Institute, Berlin, Germany

  http://orcid.org/0000-0002-8176-797X

  ⨯
• Brigitte Gertrud Dorner ,

  Contributed equally to this work with: Daniel Stern, Jasmin Weisemann, Brigitte Gertrud Dorner, Andreas Rummel

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

  * E-mail: DornerB@rki.de (BGD); Rummel.Andreas@mh-hannover.de (AR)

  Affiliation Biological Toxins (ZBS 3), Centre for Biological Threats and Special Pathogens, Robert Koch Institute, Berlin, Germany

  ⨯
• Andreas Rummel

  Contributed equally to this work with: Daniel Stern, Jasmin Weisemann, Brigitte Gertrud Dorner, Andreas Rummel

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: DornerB@rki.de (BGD); Rummel.Andreas@mh-hannover.de (AR)

  Affiliation Institut für Toxikologie, Medizinische Hochschule Hannover, Hannover, Germany

  http://orcid.org/0000-0002-0645-1641

  ⨯