Glycoengineering HIV-1 Env creates ‘supercharged’ and ‘hybrid’ glycans to increase neutralizing antibody potency, breadth and saturation

• Ema T. Crooks ,

  Contributed equally to this work with: Ema T. Crooks, Samantha L. Grimley

  Roles Data curation, Formal analysis, Investigation, Writing – review & editing

  Affiliation San Diego Biomedical Research Institute, San Diego, California, United States of America

  ⨯
• Samantha L. Grimley ,

  Contributed equally to this work with: Ema T. Crooks, Samantha L. Grimley

  Roles Data curation, Writing – review & editing

  Current address: Peter Doherty Institute for Infection and Immunity, Dept. of Microbiology & Immunology, University of Melbourne, Melbourne, Victoria, Australia

  Affiliation San Diego Biomedical Research Institute, San Diego, California, United States of America

  ⨯
• Michelle Cully,

  Roles Data curation, Investigation

  Affiliation Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

  http://orcid.org/0000-0002-3873-4929

  ⨯
• Keiko Osawa,

  Roles Data curation, Investigation, Software

  Affiliation San Diego Biomedical Research Institute, San Diego, California, United States of America

  ⨯
• Gillian Dekkers,

  Roles Conceptualization, Investigation

  Affiliation Department of Experimental Immunohematology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

  http://orcid.org/0000-0002-9127-356X

  ⨯
• Kevin Saunders,

  Roles Investigation

  Affiliation Duke University Medical Center, Durham, North Carolina, United States of America

  ⨯
• Sebastian Rämisch,

  Roles Conceptualization, Software

  Affiliations The Scripps Research Institute, Department of Immunology and Microbial Science, La Jolla, California, United States of America, IAVI Neutralizing Antibody Center, The Scripps Research Institute, Department of Immunology and Microbial Science, La Jolla, California, United States of America

  http://orcid.org/0000-0002-1801-4983

  ⨯
• Sergey Menis,

  Roles Conceptualization, Software

  Affiliations The Scripps Research Institute, Department of Immunology and Microbial Science, La Jolla, California, United States of America, IAVI Neutralizing Antibody Center, The Scripps Research Institute, Department of Immunology and Microbial Science, La Jolla, California, United States of America

  ⨯
• William R. Schief,

  Roles Conceptualization, Software

  Affiliations The Scripps Research Institute, Department of Immunology and Microbial Science, La Jolla, California, United States of America, IAVI Neutralizing Antibody Center, The Scripps Research Institute, Department of Immunology and Microbial Science, La Jolla, California, United States of America, Ragon Institute, Cambridge, Massachusetts, United States of America

  ⨯
• Nicole Doria-Rose,

  Roles Conceptualization

  Affiliation Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

  ⨯
• Barton Haynes,

  Roles Investigation

  Affiliation Duke University Medical Center, Durham, North Carolina, United States of America

  ⨯
• Ben Murrell,

  Roles Conceptualization, Software

  Affiliation Department of Medicine, University of California San Diego, San Diego, California, United States of America

  ⨯
• Evan Mitchel Cale,

  Roles Conceptualization, Data curation, Formal analysis, Writing – review & editing

  Affiliation Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

  ⨯
• Amarendra Pegu,

  Roles Data curation, Investigation

  Affiliation Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

  http://orcid.org/0000-0003-3564-6453

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• John R. Mascola,

  Roles Supervision, Writing – review & editing

  Affiliation Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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• Gestur Vidarsson,

  Roles Conceptualization, Writing – review & editing

  Affiliation Department of Experimental Immunohematology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

  http://orcid.org/0000-0001-5621-003X

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•  [ ... ],
• James M. Binley

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: jbinley@sdbri.org

  Affiliation San Diego Biomedical Research Institute, San Diego, California, United States of America

  http://orcid.org/0000-0001-5032-6111

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