PgaB orthologues contain a glycoside hydrolase domain that cleaves deacetylated poly-β(1,6)-N-acetylglucosamine and can disrupt bacterial biofilms

• Dustin J. Little ,

  Contributed equally to this work with: Dustin J. Little, Roland Pfoh

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Current address: Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada

  Affiliations Program in Molecular Medicine, The Hospital for Sick Children, Toronto, ON, Canada, Department of Biochemistry, University of Toronto, Toronto, ON, Canada

  ⨯
• Roland Pfoh ,

  Contributed equally to this work with: Dustin J. Little, Roland Pfoh

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Program in Molecular Medicine, The Hospital for Sick Children, Toronto, ON, Canada

  http://orcid.org/0000-0003-2283-3604

  ⨯
• François Le Mauff,

  Roles Formal analysis, Investigation, Methodology, Visualization, Writing – review & editing

  Affiliations Departments of Medicine and of Microbiology and Immunology, McGill University, Montréal, QC, Canada, Infectious Diseases and Immunity in Global Health Program, Research Institute of the McGill University Health Centre, Montréal, QC, Canada

  http://orcid.org/0000-0003-0712-5837

  ⨯
• Natalie C. Bamford,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliations Program in Molecular Medicine, The Hospital for Sick Children, Toronto, ON, Canada, Department of Biochemistry, University of Toronto, Toronto, ON, Canada

  http://orcid.org/0000-0003-1959-856X

  ⨯
• Christina Notte,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation Program in Molecular Medicine, The Hospital for Sick Children, Toronto, ON, Canada

  http://orcid.org/0000-0003-0278-1253

  ⨯
• Perrin Baker,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliation Program in Molecular Medicine, The Hospital for Sick Children, Toronto, ON, Canada

  http://orcid.org/0000-0001-8831-5215

  ⨯
• Manita Guragain,

  Roles Formal analysis, Investigation

  Affiliations Department of Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, NC, United States of America, Department of Microbial Infection and Immunity, The Ohio State University Wexner Medical Center, Columbus, OH, United States of America

  ⨯
• Howard Robinson,

  Roles Formal analysis, Investigation, Methodology

  Affiliation Photon Sciences Division, Brookhaven National Laboratory, Upton, NY, United States of America

  ⨯
• Gerald B. Pier,

  Roles Funding acquisition, Resources, Writing – review & editing

  Affiliation Division of Infectious Diseases, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States of America

  ⨯
• Mark Nitz,

  Roles Formal analysis, Funding acquisition, Methodology, Resources, Writing – review & editing

  Affiliation Department of Chemistry, University of Toronto, Toronto, ON, Canada

  ⨯
• Rajendar Deora,

  Roles Formal analysis, Funding acquisition, Methodology, Resources, Writing – review & editing

  Affiliations Department of Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, NC, United States of America, Department of Microbial Infection and Immunity, The Ohio State University Wexner Medical Center, Columbus, OH, United States of America

  ⨯
• Donald C. Sheppard,

  Roles Formal analysis, Funding acquisition, Methodology, Resources, Writing – review & editing

  Affiliations Departments of Medicine and of Microbiology and Immunology, McGill University, Montréal, QC, Canada, Infectious Diseases and Immunity in Global Health Program, Research Institute of the McGill University Health Centre, Montréal, QC, Canada

  ⨯
• P. Lynne Howell

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: howell@sickkids.ca

  Affiliations Program in Molecular Medicine, The Hospital for Sick Children, Toronto, ON, Canada, Department of Biochemistry, University of Toronto, Toronto, ON, Canada

  http://orcid.org/0000-0002-2776-062X

  ⨯