Titan cells formation in Cryptococcus neoformans is finely tuned by environmental conditions and modulated by positive and negative genetic regulators

• Benjamin Hommel ,

  Contributed equally to this work with: Benjamin Hommel, Liliane Mukaremera

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Resources, Visualization, Writing – original draft

  Affiliations Institut Pasteur, Molecular Mycology Unit, Département de Mycologie, Paris, France, CNRS UMR2000, Paris, France, Laboratoire de Parasitologie-Mycologie, Hôpital Saint-Louis, Groupe Hospitalier Lariboisière, Saint-Louis, Fernand Widal, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France, Université Paris Diderot, Sorbonne Paris Cité, Paris, France

  ⨯
• Liliane Mukaremera ,

  Contributed equally to this work with: Benjamin Hommel, Liliane Mukaremera

  Roles Formal analysis, Investigation, Methodology, Visualization

  Affiliation Department of Microbiology and Immunology, University of Minnesota, Minneapolis, Minnesota, United States of America

  ⨯
• Radames J. B. Cordero,

  Roles Data curation, Formal analysis, Investigation, Resources, Visualization, Writing – review & editing

  Affiliation Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD., United States of America

  http://orcid.org/0000-0002-3026-7094

  ⨯
• Carolina Coelho,

  Roles Methodology, Resources, Validation, Writing – review & editing

  Affiliation Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD., United States of America

  ⨯
• Christopher A. Desjardins,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

  Affiliation Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

  http://orcid.org/0000-0002-3160-4734

  ⨯
• Aude Sturny-Leclère,

  Roles Data curation, Formal analysis, Methodology

  Affiliations Institut Pasteur, Molecular Mycology Unit, Département de Mycologie, Paris, France, CNRS UMR2000, Paris, France

  ⨯
• Guilhem Janbon,

  Roles Methodology, Resources

  Affiliation Institut Pasteur, Unité Biologie des ARN des Pathogènes Fongiques, Département de Mycologie, Paris, France

  http://orcid.org/0000-0002-4788-1154

  ⨯
• John R. Perfect,

  Roles Resources, Validation, Writing – review & editing

  Affiliation Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America

  http://orcid.org/0000-0002-8742-3676

  ⨯
• James A. Fraser,

  Roles Conceptualization, Resources, Writing – review & editing

  Affiliation Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, Queensland, Australia

  ⨯
• Arturo Casadevall,

  Roles Conceptualization, Resources, Writing – review & editing

  Affiliation Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD., United States of America

  http://orcid.org/0000-0002-9402-9167

  ⨯
• Christina A. Cuomo,

  Roles Conceptualization, Methodology, Validation, Writing – review & editing

  Affiliation Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

  http://orcid.org/0000-0002-5778-960X

  ⨯
• Françoise Dromer,

  Roles Conceptualization, Resources, Validation, Writing – review & editing

  Affiliations Institut Pasteur, Molecular Mycology Unit, Département de Mycologie, Paris, France, CNRS UMR2000, Paris, France

  http://orcid.org/0000-0003-1671-1475

  ⨯
• Kirsten Nielsen,

  Roles Conceptualization, Methodology, Resources, Validation, Writing – review & editing

  Affiliation Department of Microbiology and Immunology, University of Minnesota, Minneapolis, Minnesota, United States of America

  ⨯
• Alexandre Alanio

  Roles Conceptualization, Data curation, Funding acquisition, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: alexandre.alanio@pasteur.fr

  Affiliations Institut Pasteur, Molecular Mycology Unit, Département de Mycologie, Paris, France, CNRS UMR2000, Paris, France, Laboratoire de Parasitologie-Mycologie, Hôpital Saint-Louis, Groupe Hospitalier Lariboisière, Saint-Louis, Fernand Widal, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France, Université Paris Diderot, Sorbonne Paris Cité, Paris, France, Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD., United States of America

  http://orcid.org/0000-0001-9726-3082

  ⨯