Limited immune surveillance in lymphoid tissue by cytolytic CD4+ T cells during health and HIV disease

• Marcus Buggert ,

  Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: marcus.buggert@ki.se (MB); betts@pennmedicine.upenn.edu (MRB)

  Affiliations Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America, Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America, Center for Infection Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden

  http://orcid.org/0000-0003-0633-1719

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• Son Nguyen,

  Roles Methodology, Writing – review & editing

  Affiliations Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America, Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America

  http://orcid.org/0000-0002-0475-5158

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• Laura M. McLane,

  Roles Formal analysis, Methodology, Visualization, Writing – review & editing

  Affiliations Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America, Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America

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• Maria Steblyanko,

  Roles Formal analysis, Methodology, Visualization

  Affiliation Microbiology and Immunology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, United States of America

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• Nadia Anikeeva,

  Roles Formal analysis, Methodology, Visualization

  Affiliation Microbiology and Immunology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, United States of America

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• Dominic Paquin-Proulx,

  Roles Methodology, Resources, Writing – review & editing

  Affiliations Center for Infection Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden, U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, United States of America

  http://orcid.org/0000-0003-1407-3414

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• Perla M. Del Rio Estrada,

  Roles Resources

  Affiliation Departamento de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico

  http://orcid.org/0000-0003-3366-3268

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• Yuria Ablanedo-Terrazas,

  Roles Resources

  Affiliation Departamento de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico

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• Kajsa Noyan,

  Roles Methodology

  Affiliation Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden

  http://orcid.org/0000-0002-1053-6832

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• Morgan A. Reuter,

  Roles Methodology, Writing – review & editing

  Affiliation Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America

  http://orcid.org/0000-0002-2304-5709

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• Korey Demers,

  Roles Methodology

  Affiliation Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America

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• Johan K. Sandberg,

  Roles Resources, Supervision, Writing – review & editing

  Affiliation Center for Infection Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden

  http://orcid.org/0000-0002-6275-0750

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• Michael A. Eller,

  Roles Resources, Writing – review & editing

  Affiliations U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, United States of America

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• Hendrik Streeck,

  Roles Resources, Writing – review & editing

  Affiliations U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, United States of America, Institute for HIV Research, University Hospital Essen, University Duisburg-Essen, Essen, Germany

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• Marianne Jansson,

  Roles Resources, Writing – review & editing

  Affiliations Department of Laboratory Medicine, Lund University, Lund, Sweden, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden

  ⨯
• Piotr Nowak,

  Roles Resources

  Affiliations Center for Infection Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden, Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden

  http://orcid.org/0000-0003-2747-0734

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• Anders Sönnerborg,

  Roles Resources

  Affiliations Center for Infection Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden, Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden

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• David H. Canaday,

  Roles Resources, Writing – review & editing

  Affiliations Division of Infectious Diseases and HIV Medicine, Case Western Reserve University, Cleveland, OH, United States of America, Geriatric Research, Education and Clinical Center, Louis Stokes VA Medical Center, Cleveland, OH, United States of America

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• Ali Naji,

  Roles Resources

  Affiliation Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America

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• E. John Wherry,

  Roles Resources, Supervision, Writing – review & editing

  Affiliations Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America, Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America

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• Merlin L. Robb,

  Roles Resources

  Affiliations U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, United States of America

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• Steven G. Deeks,

  Roles Funding acquisition, Resources, Writing – review & editing

  Affiliation Department of Medicine, University of California, San Francisco General Hospital, San Francisco, CA, United States of America

  http://orcid.org/0000-0001-6371-747X

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• Gustavo Reyes-Teran,

  Roles Funding acquisition, Resources

  Affiliation Departamento de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico

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• Yuri Sykulev,

  Roles Supervision, Validation, Writing – review & editing

  Affiliations Microbiology and Immunology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, United States of America, Medical Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, United States of America

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• Annika C. Karlsson,

  Roles Resources, Supervision, Visualization, Writing – review & editing

  Affiliation Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden

  http://orcid.org/0000-0002-2028-8393

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•  [ ... ],
• Michael R. Betts

  Roles Conceptualization, Funding acquisition, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: marcus.buggert@ki.se (MB); betts@pennmedicine.upenn.edu (MRB)

  Affiliations Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America, Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America

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