A novel Gerstmann-Sträussler-Scheinker disease mutation defines a precursor for amyloidogenic 8 kDa PrP fragments and reveals N-terminal structural changes shared by other GSS alleles

• Robert C. C. Mercer,

  Roles Conceptualization, Investigation, Writing – original draft, Writing – review & editing

  Affiliations Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada, Department of Medicine (Neurology), University of Alberta, Edmonton, Alberta, Canada

  ⨯
• Nathalie Daude,

  Roles Conceptualization, Investigation

  Affiliation Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada

  http://orcid.org/0000-0001-5217-7826

  ⨯
• Lyudmyla Dorosh,

  Roles Conceptualization, Investigation

  Affiliations National Research Council of Canada, Edmonton, Alberta, Canada, Department of Electrical and Computer Engineering, University of Alberta, Edmonton, Alberta, Canada

  http://orcid.org/0000-0002-5224-4045

  ⨯
• Ze-Lin Fu,

  Roles Investigation

  Affiliations Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada, Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada

  ⨯
• Charles E. Mays,

  Roles Investigation

  Affiliation Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada

  ⨯
• Hristina Gapeshina,

  Roles Investigation

  Affiliation Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada

  ⨯
• Serene L. Wohlgemuth,

  Roles Conceptualization, Investigation

  Affiliation Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada

  ⨯
• Claudia Y. Acevedo-Morantes,

  Roles Investigation

  Affiliation Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada

  ⨯
• Jing Yang,

  Roles Investigation

  Affiliation Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada

  http://orcid.org/0000-0002-0920-972X

  ⨯
• Neil R. Cashman,

  Roles Resources

  Affiliation Brain Research Centre, University of British Columbia, Vancouver, British Columbia, Canada

  ⨯
• Michael B. Coulthart,

  Roles Resources

  Affiliation Canadian Creutzfeldt-Jakob Disease Surveillance System, Centre for Foodborne, Environmental and Zoonotic Infectious Diseases, Public Health Agency of Canada, Ottawa, Ontario, Canada

  ⨯
• Dawn M. Pearson,

  Roles Resources

  Affiliation Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada

  http://orcid.org/0000-0002-7414-2357

  ⨯
• Jeffrey T. Joseph,

  Roles Resources

  Affiliation Hotchkiss Brain Institute and Calgary Laboratory Services, University of Calgary, Calgary, Alberta, Canada

  http://orcid.org/0000-0003-3312-5283

  ⨯
• Holger Wille,

  Roles Resources

  Affiliations Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada, Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada

  http://orcid.org/0000-0001-5102-8706

  ⨯
• Jiri G. Safar,

  Roles Resources

  Affiliation Departments of Pathology and Neurology, School of Medicine Case Western Reserve University, Cleveland, Ohio, United States of America

  http://orcid.org/0000-0003-2209-0070

  ⨯
• Gerard H. Jansen,

  Roles Investigation, Resources

  Affiliations Canadian Creutzfeldt-Jakob Disease Surveillance System, Centre for Foodborne, Environmental and Zoonotic Infectious Diseases, Public Health Agency of Canada, Ottawa, Ontario, Canada, Division of Anatomical Pathology, University of Ottawa, Ottawa, Ontario, Canada

  ⨯
• Maria Stepanova,

  Roles Conceptualization, Resources

  Affiliations National Research Council of Canada, Edmonton, Alberta, Canada, Department of Electrical and Computer Engineering, University of Alberta, Edmonton, Alberta, Canada

  ⨯
• Brian D. Sykes,

  Roles Conceptualization, Resources

  Affiliations Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada, Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada

  http://orcid.org/0000-0003-2544-2246

  ⨯
•  [ ... ],
• David Westaway

  Roles Conceptualization, Resources, Writing – original draft, Writing – review & editing

  * E-mail: david.westaway@ualberta.ca

  Affiliations Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada, Department of Medicine (Neurology), University of Alberta, Edmonton, Alberta, Canada, Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada

  http://orcid.org/0000-0003-1928-4616

  ⨯
• [ view all ]
• [ view less ]