Regional and subtype-dependent miRNA signatures in sporadic Creutzfeldt-Jakob disease are accompanied by alterations in miRNA silencing machinery and biogenesis

• Franc Llorens ,

  Contributed equally to this work with: Franc Llorens, Katrin Thüne

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: Franc.llorens@gmail.com

  Affiliations Department of Neurology, University Medical School, Göttingen, Germany, Center for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED), Barcelona, Spain

  http://orcid.org/0000-0002-9756-7497

  ⨯
• Katrin Thüne ,

  Contributed equally to this work with: Franc Llorens, Katrin Thüne

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Project administration, Writing – original draft, Writing – review & editing

  Affiliations Department of Neurology, University Medical School, Göttingen, Germany, German Center for Neurodegenerative Diseases (DZNE), Translational Studies and Biomarkers, Göttingen, Germany

  ⨯
• Eulàlia Martí,

  Roles Data curation, Formal analysis, Funding acquisition, Investigation, Software, Writing – review & editing

  Affiliation Centre for Genomic Regulation, Barcelona, Spain

  http://orcid.org/0000-0002-1030-3158

  ⨯
• Eirini Kanata,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation Prion Diseases Research Group, School of Health Sciences, Department Of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki, Greece

  ⨯
• Dimitra Dafou,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Genetics, Development and Molecular Biology, School of Biology, Aristotle University of Thessaloniki, Thessaloniki, Greece

  ⨯
• Daniela Díaz-Lucena,

  Roles Investigation, Writing – review & editing

  Affiliation Center for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED), Barcelona, Spain

  ⨯
• Ana Vivancos,

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliation Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain

  ⨯
• Orr Shomroni,

  Roles Data curation, Formal analysis, Software, Writing – review & editing

  Affiliation German Center for Neurodegenerative Diseases (DZNE), Computational Systems Biology, Göttingen, Germany

  ⨯
• Saima Zafar,

  Roles Writing – review & editing

  Affiliations Department of Neurology, University Medical School, Göttingen, Germany, German Center for Neurodegenerative Diseases (DZNE), Translational Studies and Biomarkers, Göttingen, Germany

  ⨯
• Matthias Schmitz,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliations Department of Neurology, University Medical School, Göttingen, Germany, German Center for Neurodegenerative Diseases (DZNE), Translational Studies and Biomarkers, Göttingen, Germany

  ⨯
• Uwe Michel,

  Roles Methodology, Resources, Writing – review & editing

  Affiliation Department of Neurology, University Medical School, Göttingen, Germany

  http://orcid.org/0000-0002-9302-2705

  ⨯
• Natalia Fernández-Borges,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Centro de Investigación en Sanidad Animal (CISA-INIA), Madrid, Spain

  ⨯
• Olivier Andréoletti,

  Roles Methodology, Writing – review & editing

  Affiliation Institut National de la Recherche Agronomique/Ecole Nationale Vétérinaire, Toulouse, France

  ⨯
• José Antonio del Río,

  Roles Funding acquisition, Resources, Writing – review & editing

  Affiliations Center for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED), Barcelona, Spain, Molecular and Cellular Neurobiotechnology, Catalonian Institute for Bioengineering (IBEC), Parc Científic de Barcelona, Barcelona, Spain, Department of Cell Biology, University of Barcelona, Barcelona, Spain

  http://orcid.org/0000-0002-5214-4909

  ⨯
• Juana Díez,

  Roles Funding acquisition, Resources, Writing – review & editing

  Affiliation Molecular Virology group, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain

  ⨯
• Andre Fischer,

  Roles Resources, Writing – review & editing

  Affiliation German Center for Neurodegenerative Diseases (DZNE), Epigenetics and Systems Medicine in Neurodegenerative Diseases, Göttingen, Germany

  ⨯
• Stefan Bonn,

  Roles Data curation, Formal analysis, Software, Writing – review & editing

  Affiliations German Center for Neurodegenerative Diseases (DZNE), Computational Systems Biology, Göttingen, Germany, German Center for Neurodegenerative Diseases (DZNE), Tuebingen, Germany, Center for Molecular Neurobiology University Medical Center Hamburg-Eppendorf, Hamburg, Germany

  http://orcid.org/0000-0003-4366-5662

  ⨯
• Theodoros Sklaviadis,

  Roles Resources, Writing – review & editing

  Affiliation Prion Diseases Research Group, School of Health Sciences, Department Of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki, Greece

  ⨯
• Juan Maria Torres,

  Roles Funding acquisition, Methodology, Resources, Writing – review & editing

  Affiliation Centro de Investigación en Sanidad Animal (CISA-INIA), Madrid, Spain

  http://orcid.org/0000-0003-0443-9232

  ⨯
• Isidre Ferrer ,

  Roles Conceptualization, Funding acquisition, Investigation, Project administration, Resources, Writing – review & editing

  ¶‡ IF and IZ share senior authorship of this work.

  Affiliations Center for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED), Barcelona, Spain, Senior consultant, Bellvitge University Hospital-IDIBELL, Department of Pathology and Experimental Therapeutics, University of Barcelona, Hospitalet de Llobregat, Barcelona, Spain

  ⨯
•  [ ... ],
• Inga Zerr

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Writing – review & editing

  ¶‡ IF and IZ share senior authorship of this work.

  Affiliations Department of Neurology, University Medical School, Göttingen, Germany, German Center for Neurodegenerative Diseases (DZNE), Translational Studies and Biomarkers, Göttingen, Germany

  ⨯
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