Recombinant PrP^Sc shares structural features with brain-derived PrP^Sc: Insights from limited proteolysis

• Alejandro M. Sevillano ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: amsevillano@ucsd.edu (AMS); jesus.requena@usc.es (JRR)

  Current address: Department of Pathology, UC San Diego, La Jolla, California, United States of America

  Affiliation CIMUS Biomedical Research Institute and Department of Medical Sciences University of Santiago de Compostela-IDIS, Santiago de Compostela, Spain

  http://orcid.org/0000-0002-2107-2375

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• Natalia Fernández-Borges,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft

  Current address: CISA, INIA, Madrid, Spain

  Affiliation CIC bioGUNE, Derio, Spain

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• Neelam Younas,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

  Current address: Prion Research Group, Dept. of Neurology, Universitäts Medizin Göttingen, Germany

  Affiliation CIMUS Biomedical Research Institute and Department of Medical Sciences University of Santiago de Compostela-IDIS, Santiago de Compostela, Spain

  http://orcid.org/0000-0003-0421-5247

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• Fei Wang,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft

  Affiliation Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, Michigan, United States of America

  ⨯
• Saioa R. Elezgarai,

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Writing – original draft

  Affiliation CIC bioGUNE, Derio, Spain

  http://orcid.org/0000-0001-7054-9689

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• Susana Bravo,

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Software

  Affiliation Proteomics Lab, IDIS, Santiago de Compostela, Spain

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• Ester Vázquez-Fernández,

  Roles Conceptualization, Data curation, Formal analysis, Methodology

  Current address: Structural Studies Division, MRC Laboratory of Molecular Biology, University of Cambridge, United Kingdom

  Affiliation Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Canada

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• Isaac Rosa,

  Roles Methodology

  Affiliation CIMUS Biomedical Research Institute and Department of Medical Sciences University of Santiago de Compostela-IDIS, Santiago de Compostela, Spain

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• Hasier Eraña,

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Writing – review & editing

  Affiliation CIC bioGUNE, Derio, Spain

  http://orcid.org/0000-0001-8776-4211

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• David Gil,

  Roles Data curation, Formal analysis, Methodology, Validation

  Affiliation CIC bioGUNE, Derio, Spain

  http://orcid.org/0000-0003-4241-1302

  ⨯
• Sonia Veiga,

  Roles Data curation, Methodology

  Affiliation CIMUS Biomedical Research Institute and Department of Medical Sciences University of Santiago de Compostela-IDIS, Santiago de Compostela, Spain

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• Enric Vidal,

  Roles Conceptualization, Data curation, Formal analysis, Methodology

  Affiliation Priocat Laboratory, Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Barcelona, Catalonia, Spain

  http://orcid.org/0000-0002-4965-3286

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• Melissa L. Erickson-Beltran,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization

  Affiliation USDA, ARS Western Regional Research Center, Albany, California, United States of America

  http://orcid.org/0000-0002-0505-9568

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• Esteban Guitián,

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Software, Validation

  Affiliation Mass spectrometry Core Facility, RIAIDT, University of Santiago de Compostela, Santiago de Compostela, Spain

  ⨯
• Christopher J. Silva,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation USDA, ARS Western Regional Research Center, Albany, California, United States of America

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• Romolo Nonno,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Validation, Writing – original draft, Writing – review & editing

  Affiliation Department of Veterinary Public Health and Food Safety, Istituto Superiore di Sanità, Rome, Italy

  ⨯
• Jiyan Ma,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

  Affiliation Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, Michigan, United States of America

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• Joaquín Castilla,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

  Affiliation CIC bioGUNE & IKERBasque, Bizkaia, Spain

  http://orcid.org/0000-0002-2216-1361

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•  [ ... ],
• Jesús R. Requena

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: amsevillano@ucsd.edu (AMS); jesus.requena@usc.es (JRR)

  Affiliation CIMUS Biomedical Research Institute and Department of Medical Sciences University of Santiago de Compostela-IDIS, Santiago de Compostela, Spain

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