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Open Access
Peer-reviewed
Research Article
Increased autophagic sequestration in adaptor protein-3 deficient dendritic cells limits inflammasome activity and impairs antibacterial immunity
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Adriana R. Mantegazza ,
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing
* E-mail: adrim@pennmedicine.upenn.edu (ARM); marksm@pennmedicine.upenn.edu (MSM)
Affiliations Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, United States of America, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America, Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America
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Meghan A. Wynosky-Dolfi,
Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing
Affiliation Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, United States of America
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Cierra N. Casson,
Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing
Current address: Immunology Program, Benaroya Research Institute, Seattle, WA, United States of America
Affiliation Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America
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Ariel J. Lefkovith,
Roles Data curation, Formal analysis, Investigation, Validation, Writing – review & editing
Current address: Broad Institute of MIT and Harvard, Cambridge, MA, United States of America
Affiliations Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, United States of America, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America, Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America
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Sunny Shin,
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Writing – review & editing
Affiliation Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America
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Igor E. Brodsky,
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Writing – review & editing
Affiliation Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, United States of America
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Michael S. Marks
Roles Conceptualization, Data curation, Funding acquisition, Investigation, Project administration, Resources, Software, Supervision, Writing – original draft, Writing – review & editing
* E-mail: adrim@pennmedicine.upenn.edu (ARM); marksm@pennmedicine.upenn.edu (MSM)
Affiliations Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, United States of America, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America, Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America
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Increased autophagic sequestration in adaptor protein-3 deficient dendritic cells limits inflammasome activity and impairs antibacterial immunity
- Adriana R. Mantegazza,
- Meghan A. Wynosky-Dolfi,
- Cierra N. Casson,
- Ariel J. Lefkovith,
- Sunny Shin,
- Igor E. Brodsky,
- Michael S. Marks
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- Published: December 18, 2017
- https://doi.org/10.1371/journal.ppat.1006785