Sequential inflammatory processes define human progression from M. tuberculosis infection to tuberculosis disease

• Thomas J. Scriba ,

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: thomas.scriba@uct.ac.za

  ¶‡ TJS, APN, and SS share first authorship on this work.

  Affiliation South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine & Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa

  http://orcid.org/0000-0002-0641-1359

  ⨯
• Adam Penn-Nicholson ,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  ¶‡ TJS, APN, and SS share first authorship on this work.

  Affiliation South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine & Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa

  http://orcid.org/0000-0002-1883-0059

  ⨯
• Smitha Shankar ,

  Roles Investigation, Methodology, Writing – original draft, Writing – review & editing

  ¶‡ TJS, APN, and SS share first authorship on this work.

  Affiliation The Center for Infectious Disease Research, Seattle, WA, United States of America

  ⨯
• Tom Hraha,

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Somalogic Inc, Boulder, CO, United States of America

  http://orcid.org/0000-0001-8027-2177

  ⨯
• Ethan G. Thompson,

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation The Center for Infectious Disease Research, Seattle, WA, United States of America

  ⨯
• David Sterling,

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Somalogic Inc, Boulder, CO, United States of America

  ⨯
• Elisa Nemes,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliation South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine & Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa

  ⨯
• Fatoumatta Darboe,

  Roles Methodology, Writing – review & editing

  Affiliation South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine & Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa

  http://orcid.org/0000-0001-5945-3715

  ⨯
• Sara Suliman,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliation South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine & Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa

  http://orcid.org/0000-0002-5154-576X

  ⨯
• Lynn M. Amon,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliation The Center for Infectious Disease Research, Seattle, WA, United States of America

  http://orcid.org/0000-0002-6420-7698

  ⨯
• Hassan Mahomed,

  Roles Investigation, Writing – review & editing

  Affiliations South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine & Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa, Now at Metro District Health Services, Western Cape Government: Health and Division of Public Health and Health Systems, Department of Global Health, Faculty of Health Sciences and Medicine, Stellenbosch University, Cape Town, South Africa

  http://orcid.org/0000-0001-6775-9482

  ⨯
• Mzwandile Erasmus,

  Roles Methodology, Writing – review & editing

  Affiliation South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine & Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa

  ⨯
• Wendy Whatney,

  Roles Methodology, Writing – review & editing

  Affiliation South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine & Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa

  ⨯
• John L. Johnson,

  Roles Investigation, Writing – review & editing

  Affiliation Tuberculosis Research Unit, Department of Medicine, Case Western Reserve University and University Hospitals Case Cleveland Medical Center, Cleveland, OH, United States of America

  ⨯
• W. Henry Boom,

  Roles Investigation, Writing – review & editing

  Affiliation Tuberculosis Research Unit, Department of Medicine, Case Western Reserve University and University Hospitals Case Cleveland Medical Center, Cleveland, OH, United States of America

  http://orcid.org/0000-0001-5760-9595

  ⨯
• Mark Hatherill,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine & Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa

  ⨯
• Joe Valvo,

  Roles Methodology, Writing – review & editing

  Affiliation The Center for Infectious Disease Research, Seattle, WA, United States of America

  ⨯
• Mary Ann De Groote,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Somalogic Inc, Boulder, CO, United States of America

  ⨯
• Urs A. Ochsner,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Somalogic Inc, Boulder, CO, United States of America

  http://orcid.org/0000-0003-0959-0265

  ⨯
• Alan Aderem ,

  Contributed equally to this work with: Alan Aderem, Willem A. Hanekom, Daniel E. Zak

  Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

  Affiliation The Center for Infectious Disease Research, Seattle, WA, United States of America

  ⨯
• Willem A. Hanekom ,

  Contributed equally to this work with: Alan Aderem, Willem A. Hanekom, Daniel E. Zak

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

  Affiliation South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine & Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa

  ⨯
• Daniel E. Zak ,

  Contributed equally to this work with: Alan Aderem, Willem A. Hanekom, Daniel E. Zak

  Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Supervision, Writing – original draft, Writing – review & editing

  Affiliation The Center for Infectious Disease Research, Seattle, WA, United States of America

  ⨯
•  [ ... ],
• other members of the ACS cohort study team

  ¶Membership of the ACS cohort study team is provided in the Acknowledgments.

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