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Open Access
Peer-reviewed
Research Article
TIP60 represses telomerase expression by inhibiting Sp1 binding to the TERT promoter
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Deepa Rajagopalan,
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing
Affiliations Cancer Science Institute of Singapore, National University of Singapore, Singapore, Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
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Amit Kumar Pandey,
Roles Validation, Writing – review & editing
Affiliation Cancer Science Institute of Singapore, National University of Singapore, Singapore
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Magdalene Claire Xiuzhen,
Roles Conceptualization, Methodology
Affiliations Cancer Science Institute of Singapore, National University of Singapore, Singapore, Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
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Kwok Kin Lee,
Roles Validation, Writing – review & editing
Affiliation Cancer Science Institute of Singapore, National University of Singapore, Singapore
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Shainan Hora,
Roles Methodology, Validation, Writing – review & editing
Affiliations Cancer Science Institute of Singapore, National University of Singapore, Singapore, Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
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Yanzhou Zhang,
Roles Methodology, Validation, Writing – review & editing
Affiliation Cancer Science Institute of Singapore, National University of Singapore, Singapore
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Boon Haow Chua,
Roles Validation
Affiliation Cancer Science Institute of Singapore, National University of Singapore, Singapore
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Hui Si Kwok,
Roles Validation
Affiliation Cancer Science Institute of Singapore, National University of Singapore, Singapore
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Shreshtha Sailesh Bhatia,
Roles Methodology
Affiliation Cancer Science Institute of Singapore, National University of Singapore, Singapore
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Lih Wen Deng,
Roles Supervision
Affiliation Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
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Daniel G. Tenen,
Roles Supervision
Affiliations Cancer Science Institute of Singapore, National University of Singapore, Singapore, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA, United States of America
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Dennis Kappei,
Roles Data curation, Formal analysis, Methodology, Supervision, Writing – review & editing
Affiliation Cancer Science Institute of Singapore, National University of Singapore, Singapore
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Sudhakar Jha
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing
* E-mail: csisjha@nus.edu.sg
Affiliations Cancer Science Institute of Singapore, National University of Singapore, Singapore, Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
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TIP60 represses telomerase expression by inhibiting Sp1 binding to the TERT promoter
- Deepa Rajagopalan,
- Amit Kumar Pandey,
- Magdalene Claire Xiuzhen,
- Kwok Kin Lee,
- Shainan Hora,
- Yanzhou Zhang,
- Boon Haow Chua,
- Hui Si Kwok,
- Shreshtha Sailesh Bhatia,
- Lih Wen Deng
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- Published: October 18, 2017
- https://doi.org/10.1371/journal.ppat.1006681