Merkel cell polyomavirus recruits MYCL to the EP400 complex to promote oncogenesis

Jingwei Cheng; Donglim Esther Park; Christian Berrios; Elizabeth A. White; Reety Arora; Rosa Yoon; Timothy Branigan; Tengfei Xiao; Thomas Westerling; Alexander Federation; Rhamy Zeid; Benjamin Strober; Selene K. Swanson; Laurence Florens; James E. Bradner; Myles Brown; Peter M. Howley; Megha Padi; Michael P. Washburn; James A. DeCaprio

doi:10.1371/journal.ppat.1006668

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Peer-reviewed

Research Article

Merkel cell polyomavirus recruits MYCL to the EP400 complex to promote oncogenesis

Jingwei Cheng,

Roles Conceptualization, Investigation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Donglim Esther Park,

Roles Formal analysis

Affiliations Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Graduate School of Arts and Sciences, Harvard University, Boston, Massachusetts, United States of America
⨯
Christian Berrios,

Roles Investigation

Affiliations Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Microbiology and Immunobiology, Harvard Medical School; Boston, Massachusetts, United States of America
⨯
Elizabeth A. White,

Roles Investigation

Current address: Department of Otorhinolaryngology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America

Affiliation Department of Microbiology and Immunobiology, Harvard Medical School; Boston, Massachusetts, United States of America
⨯
Reety Arora,

Roles Investigation

Current address: National Centre for Biological Sciences (NCBS), Bangalore, India

Affiliation Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

http://orcid.org/0000-0002-1871-9297

⨯
Rosa Yoon,

Roles Investigation

Affiliations Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Graduate School of Arts and Sciences, Harvard University, Boston, Massachusetts, United States of America

http://orcid.org/0000-0002-5497-5925

⨯
Timothy Branigan,

Roles Investigation

Affiliations Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Graduate School of Arts and Sciences, Harvard University, Boston, Massachusetts, United States of America

http://orcid.org/0000-0002-8641-5332

⨯
Tengfei Xiao,

Roles Software

Affiliations Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯
Thomas Westerling,

Roles Investigation

Affiliations Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Alexander Federation,

Roles Formal analysis

Affiliations Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Graduate School of Arts and Sciences, Harvard University, Boston, Massachusetts, United States of America

http://orcid.org/0000-0002-7771-1148

⨯
Rhamy Zeid,

Roles Formal analysis, Investigation

Affiliations Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Graduate School of Arts and Sciences, Harvard University, Boston, Massachusetts, United States of America
⨯
Benjamin Strober,

Roles Investigation

Affiliation Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯
Selene K. Swanson,

Roles Data curation, Investigation

Affiliation Stowers Institute for Medical Research, Kansas City, Missouri, United States of America

http://orcid.org/0000-0002-2461-2744

⨯
Laurence Florens,

Roles Data curation, Formal analysis

Affiliation Stowers Institute for Medical Research, Kansas City, Missouri, United States of America

http://orcid.org/0000-0002-9310-6650

⨯
James E. Bradner,

Roles Supervision

Current address: Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States of America

Affiliations Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Myles Brown,

Roles Supervision

Affiliations Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

http://orcid.org/0000-0002-8213-1658

⨯
Peter M. Howley,

Roles Supervision

Affiliation Department of Microbiology and Immunobiology, Harvard Medical School; Boston, Massachusetts, United States of America
⨯
Megha Padi,

Roles Formal analysis

Affiliations Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯
Michael P. Washburn,

Roles Supervision

Affiliations Stowers Institute for Medical Research, Kansas City, Missouri, United States of America, Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, United States of America
⨯
[ ... ],
James A. DeCaprio

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: james_decaprio@dfci.harvard.edu

Affiliations Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

http://orcid.org/0000-0002-0896-167X

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Merkel cell polyomavirus recruits MYCL to the EP400 complex to promote oncogenesis

Jingwei Cheng,
Donglim Esther Park,
Christian Berrios,
Elizabeth A. White,
Reety Arora,
Rosa Yoon,
Timothy Branigan,
Tengfei Xiao,
Thomas Westerling,
Alexander Federation

Published: October 13, 2017
https://doi.org/10.1371/journal.ppat.1006668

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