MyD88-dependent inflammasome activation and autophagy inhibition contributes to Ehrlichia-induced liver injury and toxic shock

• Muhamuda Kader ,

  Contributed equally to this work with: Muhamuda Kader, Mounia Alaoui-EL-Azher

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Supervision, Validation, Writing – original draft, Writing – review & editing

  Affiliation Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

  http://orcid.org/0000-0001-8902-9296

  ⨯
• Mounia Alaoui-EL-Azher ,

  Contributed equally to this work with: Muhamuda Kader, Mounia Alaoui-EL-Azher

  Roles Conceptualization, Data curation, Methodology, Writing – original draft

  Affiliation Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

  http://orcid.org/0000-0002-3209-5257

  ⨯
• Jennie Vorhauer,

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliation Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

  http://orcid.org/0000-0002-3897-6354

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• Bhushan B Kode,

  Roles Data curation, Methodology

  Affiliation Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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• Jakob Z. Wells,

  Roles Data curation, Formal analysis, Methodology

  Affiliation Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

  http://orcid.org/0000-0003-3530-8593

  ⨯
• Donna Stolz,

  Roles Funding acquisition, Methodology, Resources, Software, Visualization

  Affiliation Center for Biologic Imaging, University of Pittsburgh Medical School, Pittsburgh, Pennsylvania, United States of America

  http://orcid.org/0000-0002-1833-7010

  ⨯
• George Michalopoulos,

  Roles Funding acquisition, Investigation, Resources, Supervision

  Affiliations Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

  ⨯
• Alan Wells,

  Roles Funding acquisition, Investigation, Resources, Writing – review & editing

  Affiliations Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

  http://orcid.org/0000-0002-1637-8150

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• Melanie Scott ,

  Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Writing – original draft, Writing – review & editing

  ¶‡ These authors are co-senior authors on this work.

  Affiliations Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

  http://orcid.org/0000-0001-6864-5970

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• Nahed Ismail

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: ismailn@upmc.edu

  Affiliations Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

  ⨯