Early IL-6 signalling promotes IL-27 dependent maturation of regulatory T cells in the lungs and resolution of viral immunopathology

Chloe J. Pyle; Faith I. Uwadiae; David P. Swieboda; James A. Harker

doi:10.1371/journal.ppat.1006640

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Peer-reviewed

Research Article

Early IL-6 signalling promotes IL-27 dependent maturation of regulatory T cells in the lungs and resolution of viral immunopathology

Chloe J. Pyle,

Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Writing – review & editing

Affiliation Section of Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, South Kensington Campus, South Kensington, London, United Kingdom

http://orcid.org/0000-0002-1408-1134

⨯
Faith I. Uwadiae,

Roles Data curation, Investigation, Writing – review & editing

Affiliations Section of Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, South Kensington Campus, South Kensington, London, United Kingdom, MRC & Asthma UK Centre in Allergic Mechanisms for Asthma, London, United Kingdom

http://orcid.org/0000-0002-6660-6051

⨯
David P. Swieboda,

Roles Formal analysis, Investigation, Methodology

Affiliations Section of Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, South Kensington Campus, South Kensington, London, United Kingdom, MRC & Asthma UK Centre in Allergic Mechanisms for Asthma, London, United Kingdom
⨯
James A. Harker

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: j.harker@imperial.ac.uk

Affiliations Section of Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, South Kensington Campus, South Kensington, London, United Kingdom, MRC & Asthma UK Centre in Allergic Mechanisms for Asthma, London, United Kingdom

http://orcid.org/0000-0002-0301-6898

⨯

Early IL-6 signalling promotes IL-27 dependent maturation of regulatory T cells in the lungs and resolution of viral immunopathology

Chloe J. Pyle,
Faith I. Uwadiae,
David P. Swieboda,
James A. Harker

Published: September 27, 2017
https://doi.org/10.1371/journal.ppat.1006640

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T cells
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Regulatory T cells
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Respiratory infections
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Influenza A virus
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