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Open Access
Peer-reviewed
Research Article
Supraphysiologic control over HIV-1 replication mediated by CD8 T cells expressing a re-engineered CD4-based chimeric antigen receptor
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Rachel S. Leibman,
Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing
Affiliations Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
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Max W. Richardson,
Roles Investigation
Affiliations Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
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Christoph T. Ellebrecht,
Roles Conceptualization, Investigation
Affiliation Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
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Colby R. Maldini,
Roles Investigation
Affiliations Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
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Joshua A. Glover,
Roles Investigation
Affiliation Department of Medicine and Center for AIDS Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
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Anthony J. Secreto,
Roles Methodology, Supervision
Affiliation Department of Medicine and Center for AIDS Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
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Irina Kulikovskaya,
Roles Investigation
Affiliation Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
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Simon F. Lacey,
Roles Methodology, Supervision
Affiliation Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
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Sarah R. Akkina,
Roles Investigation
Affiliation Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
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Yanjie Yi,
Roles Investigation
Affiliation Department of Medicine and Center for AIDS Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
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Farida Shaheen,
Roles Investigation
Affiliation Department of Medicine and Center for AIDS Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
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Jianbin Wang,
Roles Investigation
Affiliation Sangamo BioSciences Inc., Richmond, California, United States of America
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Keith A. Dufendach,
Roles Investigation
Affiliations Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
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Michael C. Holmes,
Roles Supervision
Affiliation Sangamo BioSciences Inc., Richmond, California, United States of America
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Ronald G. Collman,
Roles Supervision
Affiliation Department of Medicine and Center for AIDS Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
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Aimee S. Payne,
Roles Conceptualization, Supervision
Affiliation Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
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James L. Riley
Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing
* E-mail: rileyj@upenn.edu
Affiliations Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
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Supraphysiologic control over HIV-1 replication mediated by CD8 T cells expressing a re-engineered CD4-based chimeric antigen receptor
- Rachel S. Leibman,
- Max W. Richardson,
- Christoph T. Ellebrecht,
- Colby R. Maldini,
- Joshua A. Glover,
- Anthony J. Secreto,
- Irina Kulikovskaya,
- Simon F. Lacey,
- Sarah R. Akkina,
- Yanjie Yi
- Published: October 12, 2017
- https://doi.org/10.1371/journal.ppat.1006613