Destabilizing polymorphism in cervid prion protein hydrophobic core determines prion conformation and conversion efficiency

• Samia Hannaoui,

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Ecosystem and Public Health, Calgary Prion Research Unit, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada

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• Sara Amidian,

  Roles Data curation, Formal analysis, Methodology, Software, Writing – original draft

  Affiliations Center for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada, Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada

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• Yo Ching Cheng,

  Roles Methodology

  Affiliation Department of Ecosystem and Public Health, Calgary Prion Research Unit, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada

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• Camilo Duque Velásquez,

  Roles Data curation, Methodology

  Affiliation Center for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada

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• Lyudmyla Dorosh,

  Roles Formal analysis, Methodology, Software

  Affiliation Department of Electrical and Computer Engineering, University of Alberta, Edmonton, Alberta, Canada

  http://orcid.org/0000-0002-5224-4045

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• Sampson Law,

  Roles Methodology

  Affiliation Department of Ecosystem and Public Health, Calgary Prion Research Unit, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada

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• Glenn Telling,

  Roles Resources

  Affiliation Prion Research Center, Colorado State University, Fort Collins, Colorado, United States of America

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• Maria Stepanova,

  Roles Formal analysis, Software

  Affiliation Department of Electrical and Computer Engineering, University of Alberta, Edmonton, Alberta, Canada

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• Debbie McKenzie,

  Roles Resources

  Affiliation Center for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada

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• Holger Wille,

  Roles Data curation, Formal analysis, Methodology, Resources, Software, Validation, Writing – original draft, Writing – review & editing

  Affiliations Center for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada, Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada

  http://orcid.org/0000-0001-5102-8706

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• Sabine Gilch

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: sgilch@ucalgary.ca

  Affiliation Department of Ecosystem and Public Health, Calgary Prion Research Unit, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada

  http://orcid.org/0000-0001-5923-3464

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