Bacterial effector NleL promotes enterohemorrhagic E. coli-induced attaching and effacing lesions by ubiquitylating and inactivating JNK

Xiangpeng Sheng; Qing You; Hongnian Zhu; ZeNan Chang; Qingrun Li; Haifeng Wang; Chen Wang; Hongyan Wang; Lijian Hui; Chongtao Du; Xiaoduo Xie; Rong Zeng; Anning Lin; Dongfang Shi; Kangcheng Ruan; Jinghua Yan; George Fu Gao; Feng Shao; Ronggui Hu

doi:10.1371/journal.ppat.1006534

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Peer-reviewed

Research Article

Bacterial effector NleL promotes enterohemorrhagic E. coli-induced attaching and effacing lesions by ubiquitylating and inactivating JNK

Xiangpeng Sheng ,

Contributed equally to this work with: Xiangpeng Sheng, Qing You

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China, University of Chinese Academy of Sciences, Beijing, China
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Qing You ,

Contributed equally to this work with: Xiangpeng Sheng, Qing You

Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Validation, Visualization, Writing – review & editing

Affiliations State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China, University of Chinese Academy of Sciences, Beijing, China
⨯
Hongnian Zhu,

Roles Investigation, Methodology, Resources

Affiliation College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, China
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ZeNan Chang,

Roles Funding acquisition, Resources, Writing – review & editing

Affiliation David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, United States of America
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Qingrun Li,

Roles Investigation, Methodology, Resources

Affiliation State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
⨯
Haifeng Wang,

Roles Investigation, Methodology, Resources

Affiliation State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
⨯
Chen Wang,

Roles Resources

Affiliation State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
⨯
Hongyan Wang,

Roles Resources, Writing – review & editing

Affiliation State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
⨯
Lijian Hui,

Roles Resources

Affiliation State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
⨯
Chongtao Du,

Roles Resources

Affiliation College of Veterinary Medicine, Jilin University, Changchun, Jilin, China
⨯
Xiaoduo Xie,

Roles Resources

Affiliation State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
⨯
Rong Zeng,

Roles Resources

Affiliation State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
⨯
Anning Lin,

Roles Resources

Affiliations State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China, Ben May Department for Cancer Research, University of Chicago, Chicago, Illinois, United States of America
⨯
Dongfang Shi,

Roles Resources

Affiliation College of Veterinary Medicine, Northeast Agricultural University, Harbin, Heilongjiang, China
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Kangcheng Ruan,

Roles Resources

Affiliation State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
⨯
Jinghua Yan,

Roles Resources

Affiliation Beijing Institute of microbiology, Chinese Academy of Sciences, Beijing, China
⨯
George Fu Gao,

Roles Funding acquisition, Resources

Affiliation Beijing Institute of microbiology, Chinese Academy of Sciences, Beijing, China
⨯
Feng Shao,

Roles Resources, Writing – review & editing

Affiliation National Institute of Biological Sciences, Beijing, China
⨯
[ ... ],
Ronggui Hu

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: coryhu@sibcb.ac.cn

Affiliation State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China

http://orcid.org/0000-0001-8323-239X

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Bacterial effector NleL promotes enterohemorrhagic E. coli-induced attaching and effacing lesions by ubiquitylating and inactivating JNK

Xiangpeng Sheng,
Qing You,
Hongnian Zhu,
ZeNan Chang,
Qingrun Li,
Haifeng Wang,
Chen Wang,
Hongyan Wang,
Lijian Hui,
Chongtao Du

Published: July 28, 2017
https://doi.org/10.1371/journal.ppat.1006534

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Enterohaemorrhagic Escherichia coli
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