Hypoxia-inducible factor-1α plays roles in Epstein-Barr virus’s natural life cycle and tumorigenesis by inducing lytic infection through direct binding to the immediate-early BZLF1 gene promoter

Richard J. Kraus; Xianming Yu; Blue-leaf A. Cordes; Saraniya Sathiamoorthi; Tawin Iempridee; Dhananjay M. Nawandar; Shidong Ma; James C. Romero-Masters; Kyle G. McChesney; Zhen Lin; Kathleen R. Makielski; Denis L. Lee; Paul F. Lambert; Eric C. Johannsen; Shannon C. Kenney; Janet E. Mertz

doi:10.1371/journal.ppat.1006404

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Research Article

Hypoxia-inducible factor-1α plays roles in Epstein-Barr virus’s natural life cycle and tumorigenesis by inducing lytic infection through direct binding to the immediate-early BZLF1 gene promoter

Richard J. Kraus,

Affiliation McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, United States of America
⨯
Xianming Yu,

Affiliation McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, United States of America

http://orcid.org/0000-0002-2186-3062

⨯
Blue-leaf A. Cordes,

Affiliation McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, United States of America
⨯
Saraniya Sathiamoorthi,

Affiliation McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, United States of America

http://orcid.org/0000-0003-1843-7270

⨯
Tawin Iempridee,

Affiliation National Nanotechnology Center, National Science and Technology Development Agency, Thailand Science Park, Pathum Thani, Thailand

http://orcid.org/0000-0001-9128-4894

⨯
Dhananjay M. Nawandar,

Affiliation McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, United States of America
⨯
Shidong Ma,

Affiliation McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, United States of America
⨯
James C. Romero-Masters,

Affiliation McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, United States of America

http://orcid.org/0000-0001-6871-0568

⨯
Kyle G. McChesney,

Affiliation McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, United States of America
⨯
Zhen Lin,

Affiliation Department of Pathology, Tulane University Health Sciences Center and Tulane Cancer Center, New Orleans, Louisiana, United States of America
⨯
Kathleen R. Makielski,

Affiliation McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, United States of America
⨯
Denis L. Lee,

Affiliation McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, United States of America
⨯
Paul F. Lambert,

Affiliation McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, United States of America
⨯
Eric C. Johannsen,

Affiliations McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, United States of America, Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, United States of America
⨯
Shannon C. Kenney,

Affiliations McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, United States of America, Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, United States of America
⨯
[ ... ],
Janet E. Mertz

* E-mail: mertz@oncology.wisc.edu

Affiliation McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, United States of America

http://orcid.org/0000-0002-4754-7594

⨯
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Hypoxia-inducible factor-1α plays roles in Epstein-Barr virus’s natural life cycle and tumorigenesis by inducing lytic infection through direct binding to the immediate-early BZLF1 gene promoter

Richard J. Kraus,
Xianming Yu,
Blue-leaf A. Cordes,
Saraniya Sathiamoorthi,
Tawin Iempridee,
Dhananjay M. Nawandar,
Shidong Ma,
James C. Romero-Masters,
Kyle G. McChesney,
Zhen Lin

Published: June 15, 2017
https://doi.org/10.1371/journal.ppat.1006404

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