Suppression of IL-12p70 formation by IL-2 or following macrophage depletion causes T-cell autoreactivity leading to CNS demyelination in HSV-1-infected mice

Dhong Hyun Lee; Mandana Zandian; Jane Kuo; Kevin R. Mott; Shuang Chen; Moshe Arditi; Homayon Ghiasi

doi:10.1371/journal.ppat.1006401

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Peer-reviewed

Research Article

Suppression of IL-12p70 formation by IL-2 or following macrophage depletion causes T-cell autoreactivity leading to CNS demyelination in HSV-1-infected mice

Dhong Hyun Lee,

Affiliation Center for Neurobiology and Vaccine Development, Ophthalmology Research, Department of Surgery, Cedars-Sinai Burns & Allen Research Institute, CSMC – SSB3, Los Angeles, California, United States of America
⨯
Mandana Zandian,

Affiliation Center for Neurobiology and Vaccine Development, Ophthalmology Research, Department of Surgery, Cedars-Sinai Burns & Allen Research Institute, CSMC – SSB3, Los Angeles, California, United States of America
⨯
Jane Kuo,

Affiliation Center for Neurobiology and Vaccine Development, Ophthalmology Research, Department of Surgery, Cedars-Sinai Burns & Allen Research Institute, CSMC – SSB3, Los Angeles, California, United States of America

http://orcid.org/0000-0001-5806-6940

⨯
Kevin R. Mott,

Affiliation Center for Neurobiology and Vaccine Development, Ophthalmology Research, Department of Surgery, Cedars-Sinai Burns & Allen Research Institute, CSMC – SSB3, Los Angeles, California, United States of America
⨯
Shuang Chen,

Affiliation Division of Pediatric Infectious Diseases and Immunology, CSMC, Los Angeles, California, United States of America
⨯
Moshe Arditi,

Affiliation Division of Pediatric Infectious Diseases and Immunology, CSMC, Los Angeles, California, United States of America

http://orcid.org/0000-0001-9042-2909

⨯
Homayon Ghiasi

* E-mail: ghiasih@CSHS.org

Affiliation Center for Neurobiology and Vaccine Development, Ophthalmology Research, Department of Surgery, Cedars-Sinai Burns & Allen Research Institute, CSMC – SSB3, Los Angeles, California, United States of America

http://orcid.org/0000-0003-3291-1995

⨯

Suppression of IL-12p70 formation by IL-2 or following macrophage depletion causes T-cell autoreactivity leading to CNS demyelination in HSV-1-infected mice

Dhong Hyun Lee,
Mandana Zandian,
Jane Kuo,
Kevin R. Mott,
Shuang Chen,
Moshe Arditi,
Homayon Ghiasi

Published: May 22, 2017
https://doi.org/10.1371/journal.ppat.1006401

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