Detection of a microbial metabolite by STING regulates inflammasome activation in response to Chlamydia trachomatis infection

Steve J. Webster; Sven Brode; Lou Ellis; Timothy J. Fitzmaurice; Matthew J. Elder; Nelson O. Gekara; Panagiotis Tourlomousis; Clare Bryant; Simon Clare; Ronnie Chee; Hill J. S. Gaston; Jane C. Goodall

doi:10.1371/journal.ppat.1006383

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Open Access

Peer-reviewed

Research Article

Detection of a microbial metabolite by STING regulates inflammasome activation in response to Chlamydia trachomatis infection

Steve J. Webster ,

* E-mail: jcg23@medschl.cam.ac.uk (JCG); sjw231@medschl.cam.ac.uk (SJW)

Affiliation Rheumatology Research Group, Department of Medicine, University of Cambridge, Cambridge, United Kingdom

http://orcid.org/0000-0002-0864-1182

⨯
Sven Brode,

Affiliation Rheumatology Research Group, Department of Medicine, University of Cambridge, Cambridge, United Kingdom
⨯
Lou Ellis,

Affiliation Rheumatology Research Group, Department of Medicine, University of Cambridge, Cambridge, United Kingdom
⨯
Timothy J. Fitzmaurice,

Affiliation Rheumatology Research Group, Department of Medicine, University of Cambridge, Cambridge, United Kingdom
⨯
Matthew J. Elder,

Affiliation Rheumatology Research Group, Department of Medicine, University of Cambridge, Cambridge, United Kingdom
⨯
Nelson O. Gekara,

Affiliation Molecular Infection Medicine Sweden, Umeå Centre for Microbial Research, Department of Molecular Biology, Umeå University, Umeå, Sweden
⨯
Panagiotis Tourlomousis,

Affiliation Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom
⨯
Clare Bryant,

Affiliation Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom

http://orcid.org/0000-0002-2924-0038

⨯
Simon Clare,

Affiliation Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom
⨯
Ronnie Chee,

Affiliation Department of Immunology, Royal Free Hospital, London, United Kingdom
⨯
Hill J. S. Gaston,

Affiliation Rheumatology Research Group, Department of Medicine, University of Cambridge, Cambridge, United Kingdom
⨯
Jane C. Goodall

* E-mail: jcg23@medschl.cam.ac.uk (JCG); sjw231@medschl.cam.ac.uk (SJW)

Affiliation Rheumatology Research Group, Department of Medicine, University of Cambridge, Cambridge, United Kingdom
⨯

Detection of a microbial metabolite by STING regulates inflammasome activation in response to Chlamydia trachomatis infection

Steve J. Webster,
Sven Brode,
Lou Ellis,
Timothy J. Fitzmaurice,
Matthew J. Elder,
Nelson O. Gekara,
Panagiotis Tourlomousis,
Clare Bryant,
Simon Clare,
Ronnie Chee

Published: June 1, 2017
https://doi.org/10.1371/journal.ppat.1006383

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Chlamydia trachomatis
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Inflammasomes
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Chlamydia infection
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Interferons
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Cell death
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Macrophages
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Secretion
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