Mycobacterium tuberculosis subverts negative regulatory pathways in human macrophages to drive immunopathology

Patience T. Brace; Liku B. Tezera; Magdalena K. Bielecka; Toby Mellows; Diana Garay; Shuye Tian; Lucinda Rand; Justin Green; Sanjay Jogai; Andrew J. Steele; Timothy M. Millar; Tilman Sanchez-Elsner; Jon S. Friedland; Christopher G. Proud; Paul T. Elkington

doi:10.1371/journal.ppat.1006367

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Open Access

Peer-reviewed

Research Article

Mycobacterium tuberculosis subverts negative regulatory pathways in human macrophages to drive immunopathology

Patience T. Brace,

Affiliation NIHR Biomedical Research Centre, Clinical and Experimental Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom

http://orcid.org/0000-0002-9146-4542

⨯
Liku B. Tezera,

Affiliation NIHR Biomedical Research Centre, Clinical and Experimental Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom

http://orcid.org/0000-0002-7898-6709

⨯
Magdalena K. Bielecka,

Affiliation NIHR Biomedical Research Centre, Clinical and Experimental Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
⨯
Toby Mellows,

Affiliation NIHR Biomedical Research Centre, Clinical and Experimental Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom

http://orcid.org/0000-0002-5241-0760

⨯
Diana Garay,

Affiliation NIHR Biomedical Research Centre, Clinical and Experimental Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom

http://orcid.org/0000-0002-9450-8504

⨯
Shuye Tian,

Affiliation South Australian Health and Medical Research Institute, Adelaide, and School of Biological Sciences, University of Adelaide, Adelaide, Australia
⨯
Lucinda Rand,

Affiliation Department of Infectious Diseases and Immunity, Imperial College London, London, United Kingdom
⨯
Justin Green,

Affiliation Department of Infectious Diseases and Immunity, Imperial College London, London, United Kingdom
⨯
Sanjay Jogai,

Affiliation NIHR Biomedical Research Centre, Clinical and Experimental Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
⨯
Andrew J. Steele,

Affiliation Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
⨯
Timothy M. Millar,

Affiliation NIHR Biomedical Research Centre, Clinical and Experimental Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom

http://orcid.org/0000-0002-4539-2445

⨯
Tilman Sanchez-Elsner,

Affiliation NIHR Biomedical Research Centre, Clinical and Experimental Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
⨯
Jon S. Friedland,

Affiliation Department of Infectious Diseases and Immunity, Imperial College London, London, United Kingdom

http://orcid.org/0000-0001-7789-9649

⨯
Christopher G. Proud,

Affiliation South Australian Health and Medical Research Institute, Adelaide, and School of Biological Sciences, University of Adelaide, Adelaide, Australia
⨯
Paul T. Elkington

* E-mail: p.elkington@soton.ac.uk

Affiliations NIHR Biomedical Research Centre, Clinical and Experimental Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom, Institute for Life Sciences, University of Southampton, Southampton, United Kingdom

http://orcid.org/0000-0003-0390-0613

⨯

Mycobacterium tuberculosis subverts negative regulatory pathways in human macrophages to drive immunopathology

Patience T. Brace,
Liku B. Tezera,
Magdalena K. Bielecka,
Toby Mellows,
Diana Garay,
Shuye Tian,
Lucinda Rand,
Justin Green,
Sanjay Jogai,
Andrew J. Steele

Published: June 1, 2017
https://doi.org/10.1371/journal.ppat.1006367

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Mycobacterium tuberculosis
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Macrophages
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Secretion
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Gene expression
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Cytokines
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MicroRNAs
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Tuberculosis
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MAPK signaling cascades
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