Genetically-barcoded SIV facilitates enumeration of rebound variants and estimation of reactivation rates in nonhuman primates following interruption of suppressive antiretroviral therapy

Christine M. Fennessey; Mykola Pinkevych; Taina T. Immonen; Arnold Reynaldi; Vanessa Venturi; Priyanka Nadella; Carolyn Reid; Laura Newman; Leslie Lipkey; Kelli Oswald; William J. Bosche; Matthew T. Trivett; Claes Ohlen; David E. Ott; Jacob D. Estes; Gregory Q. Del Prete; Jeffrey D. Lifson; Miles P. Davenport; Brandon F. Keele

doi:10.1371/journal.ppat.1006359

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Peer-reviewed

Research Article

Genetically-barcoded SIV facilitates enumeration of rebound variants and estimation of reactivation rates in nonhuman primates following interruption of suppressive antiretroviral therapy

Christine M. Fennessey,

Affiliation AIDS and Cancer Virus Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America

http://orcid.org/0000-0002-8736-8523

⨯
Mykola Pinkevych,

Affiliation Infection Analytics Program, Kirby Institute for Infection and Immunity, UNSW Australia, Sydney, NSW, Australia
⨯
Taina T. Immonen,

Affiliation AIDS and Cancer Virus Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America

http://orcid.org/0000-0003-4521-0696

⨯
Arnold Reynaldi,

Affiliation Infection Analytics Program, Kirby Institute for Infection and Immunity, UNSW Australia, Sydney, NSW, Australia
⨯
Vanessa Venturi,

Affiliation Infection Analytics Program, Kirby Institute for Infection and Immunity, UNSW Australia, Sydney, NSW, Australia

http://orcid.org/0000-0003-3340-2367

⨯
Priyanka Nadella,

Affiliation AIDS and Cancer Virus Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America

http://orcid.org/0000-0002-9017-0585

⨯
Carolyn Reid,

Affiliation AIDS and Cancer Virus Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America
⨯
Laura Newman,

Affiliation AIDS and Cancer Virus Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America
⨯
Leslie Lipkey,

Affiliation AIDS and Cancer Virus Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America
⨯
Kelli Oswald,

Affiliation AIDS and Cancer Virus Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America

http://orcid.org/0000-0003-2327-8497

⨯
William J. Bosche,

Affiliation AIDS and Cancer Virus Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America
⨯
Matthew T. Trivett,

Affiliation AIDS and Cancer Virus Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America

http://orcid.org/0000-0002-2165-4367

⨯
Claes Ohlen †,

† Deceased.

Affiliation AIDS and Cancer Virus Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America

http://orcid.org/0000-0002-2381-1151

⨯
David E. Ott,

Affiliation AIDS and Cancer Virus Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America
⨯
Jacob D. Estes,

Affiliation AIDS and Cancer Virus Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America
⨯
Gregory Q. Del Prete,

Affiliation AIDS and Cancer Virus Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America
⨯
Jeffrey D. Lifson,

Affiliation AIDS and Cancer Virus Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America
⨯
Miles P. Davenport ,

* E-mail: keelebf@mail.nih.gov (BFK); m.davenport@unsw.edu.au (MPD)

Affiliation Infection Analytics Program, Kirby Institute for Infection and Immunity, UNSW Australia, Sydney, NSW, Australia
⨯
[ ... ],
Brandon F. Keele

* E-mail: keelebf@mail.nih.gov (BFK); m.davenport@unsw.edu.au (MPD)

Affiliation AIDS and Cancer Virus Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America
⨯
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Genetically-barcoded SIV facilitates enumeration of rebound variants and estimation of reactivation rates in nonhuman primates following interruption of suppressive antiretroviral therapy

Christine M. Fennessey,
Mykola Pinkevych,
Taina T. Immonen,
Arnold Reynaldi,
Vanessa Venturi,
Priyanka Nadella,
Carolyn Reid,
Laura Newman,
Leslie Lipkey,
Kelli Oswald

Published: May 4, 2017
https://doi.org/10.1371/journal.ppat.1006359

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