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Open Access
Peer-reviewed
Research Article
HIV-1 competition experiments in humanized mice show that APOBEC3H imposes selective pressure and promotes virus adaptation
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Yusuke Nakano,
Affiliation Laboratory of Systems Virology, Department of Biosystems Science, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan
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Naoko Misawa,
Affiliation Laboratory of Systems Virology, Department of Biosystems Science, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan
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Guillermo Juarez-Fernandez,
Affiliation Laboratory of Systems Virology, Department of Biosystems Science, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan
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Miyu Moriwaki,
Affiliations Laboratory of Systems Virology, Department of Biosystems Science, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan, Graduate School of Biostudies, Kyoto University, Kyoto, Japan
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Shinji Nakaoka,
Affiliations Institute of Industrial Sciences, The University of Tokyo, Meguro-ku, Tokyo, Japan, PRESTO, Japan Science and Technology Agency, Kawaguchi, Saitama, Japan
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Takaaki Funo,
Affiliation Mathematical Biology Laboratory, Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka, Japan
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Eri Yamada,
Affiliation Laboratory of Systems Virology, Department of Biosystems Science, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan
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Andrew Soper,
Affiliation Laboratory of Systems Virology, Department of Biosystems Science, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan
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Rokusuke Yoshikawa,
Current address: Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan
Affiliation Laboratory of Systems Virology, Department of Biosystems Science, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan
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Diako Ebrahimi,
Affiliations Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, United States of America, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, United States of America, Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota, United States of America, Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota, United States of America
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Yuuya Tachiki,
Affiliations Laboratory of Systems Virology, Department of Biosystems Science, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan, Mathematical Biology Laboratory, Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka, Japan, CREST, Japan Science and Technology Agency, Kawaguchi, Saitama, Japan
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Shingo Iwami,
Affiliations PRESTO, Japan Science and Technology Agency, Kawaguchi, Saitama, Japan, Mathematical Biology Laboratory, Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka, Japan, CREST, Japan Science and Technology Agency, Kawaguchi, Saitama, Japan
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Reuben S. Harris,
Affiliations Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, United States of America, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, United States of America, Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota, United States of America, Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota, United States of America, Howard Hughes Medical Institute, University of Minnesota, Minneapolis, Minnesota, United States of America
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Yoshio Koyanagi,
Affiliation Laboratory of Systems Virology, Department of Biosystems Science, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan
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Kei Sato
* E-mail: ksato@virus.kyoto-u.ac.jp
Affiliations Laboratory of Systems Virology, Department of Biosystems Science, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan, CREST, Japan Science and Technology Agency, Kawaguchi, Saitama, Japan
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HIV-1 competition experiments in humanized mice show that APOBEC3H imposes selective pressure and promotes virus adaptation
- Yusuke Nakano,
- Naoko Misawa,
- Guillermo Juarez-Fernandez,
- Miyu Moriwaki,
- Shinji Nakaoka,
- Takaaki Funo,
- Eri Yamada,
- Andrew Soper,
- Rokusuke Yoshikawa,
- Diako Ebrahimi
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- Published: May 5, 2017
- https://doi.org/10.1371/journal.ppat.1006348