Interferon-inducible ribonuclease ISG20 inhibits hepatitis B virus replication through directly binding to the epsilon stem-loop structure of viral RNA

Yuanjie Liu; Hui Nie; Richeng Mao; Bidisha Mitra; Dawei Cai; Ran Yan; Ju-Tao Guo; Timothy M. Block; Nadir Mechti; Haitao Guo

doi:10.1371/journal.ppat.1006296

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Open Access

Peer-reviewed

Research Article

Interferon-inducible ribonuclease ISG20 inhibits hepatitis B virus replication through directly binding to the epsilon stem-loop structure of viral RNA

Yuanjie Liu,

Affiliation Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Hui Nie,

Affiliation Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America

http://orcid.org/0000-0001-8827-8872

⨯
Richeng Mao,

Affiliation Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Bidisha Mitra,

Affiliation Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Dawei Cai,

Affiliation Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Ran Yan,

Affiliation Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Ju-Tao Guo,

Affiliation Baruch S. Blumberg Institute, Doylestown, Pennsylvania, United States of America
⨯
Timothy M. Block,

Affiliation Baruch S. Blumberg Institute, Doylestown, Pennsylvania, United States of America
⨯
Nadir Mechti,

Affiliation CNRS, UMR5235, DIMNP, University of Montpellier 2, Montpellier, France
⨯
Haitao Guo

* E-mail: haitguo@iupui.edu

Affiliation Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America

http://orcid.org/0000-0002-7146-916X

⨯

Interferon-inducible ribonuclease ISG20 inhibits hepatitis B virus replication through directly binding to the epsilon stem-loop structure of viral RNA

Yuanjie Liu,
Hui Nie,
Richeng Mao,
Bidisha Mitra,
Dawei Cai,
Ran Yan,
Ju-Tao Guo,
Timothy M. Block,
Nadir Mechti,
Haitao Guo

Published: April 11, 2017
https://doi.org/10.1371/journal.ppat.1006296

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Plasmid construction
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Transfection
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DNA replication
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Small interfering RNA
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Hepatitis B virus
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