Proviruses with identical sequences comprise a large fraction of the replication-competent HIV reservoir

John K. Bui; Michele D. Sobolewski; Brandon F. Keele; Jonathan Spindler; Andrew Musick; Ann Wiegand; Brian T. Luke; Wei Shao; Stephen H. Hughes; John M. Coffin; Mary F. Kearney; John W. Mellors

doi:10.1371/journal.ppat.1006283

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Open Access

Peer-reviewed

Research Article

Proviruses with identical sequences comprise a large fraction of the replication-competent HIV reservoir

John K. Bui,

Affiliations Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, Howard Hughes Medical Research Fellows Program, Howard Hughes Medical Institute, Bethesda, Maryland, United States of America

http://orcid.org/0000-0001-5905-2049

⨯
Michele D. Sobolewski,

Affiliation Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Brandon F. Keele,

Affiliation AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research operated by Leidos Biomedical Research, Inc., Frederick, Maryland, United States of America
⨯
Jonathan Spindler,

Affiliation HIV Dynamics and Replication Program, National Cancer Institute, Frederick, Maryland, United States of America
⨯
Andrew Musick,

Affiliation HIV Dynamics and Replication Program, National Cancer Institute, Frederick, Maryland, United States of America

http://orcid.org/0000-0002-0470-9880

⨯
Ann Wiegand,

Affiliation HIV Dynamics and Replication Program, National Cancer Institute, Frederick, Maryland, United States of America
⨯
Brian T. Luke,

Affiliation Advanced Biomedical Computing Center, Frederick National Laboratory for Cancer Research operated by Leidos Biomedical Research, Inc., Frederick, Maryland, United States of America

http://orcid.org/0000-0002-2777-7376

⨯
Wei Shao,

Affiliation Advanced Biomedical Computing Center, Frederick National Laboratory for Cancer Research operated by Leidos Biomedical Research, Inc., Frederick, Maryland, United States of America
⨯
Stephen H. Hughes,

Affiliation HIV Dynamics and Replication Program, National Cancer Institute, Frederick, Maryland, United States of America
⨯
John M. Coffin,

Affiliation Department of Molecular Biology and Microbiology, Tufts University, Boston, Massachusetts, United States of America
⨯
Mary F. Kearney,

Affiliation HIV Dynamics and Replication Program, National Cancer Institute, Frederick, Maryland, United States of America
⨯
John W. Mellors

* E-mail: jwm1@pitt.edu

Affiliation Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯

Proviruses with identical sequences comprise a large fraction of the replication-competent HIV reservoir

John K. Bui,
Michele D. Sobolewski,
Brandon F. Keele,
Jonathan Spindler,
Andrew Musick,
Ann Wiegand,
Brian T. Luke,
Wei Shao,
Stephen H. Hughes,
John M. Coffin

Published: March 22, 2017
https://doi.org/10.1371/journal.ppat.1006283

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