HPV16 and 18 genome amplification show different E4-dependence, with 16E4 enhancing E1 nuclear accumulation and replicative efficiency via its cell cycle arrest and kinase activation functions

• Nagayasu Egawa ,

  Contributed equally to this work with: Nagayasu Egawa, Qian Wang, Heather M. Griffin

  Affiliations Department of Pathology, University of Cambridge, Cambridge, United Kingdom, Francis Crick Institute, Mill Hill Laboratory, The Ridgeway, Mill Hill, London, United Kingdom

  ⨯
• Qian Wang ,

  Contributed equally to this work with: Nagayasu Egawa, Qian Wang, Heather M. Griffin

  Affiliation Francis Crick Institute, Mill Hill Laboratory, The Ridgeway, Mill Hill, London, United Kingdom

  ⨯
• Heather M. Griffin ,

  Contributed equally to this work with: Nagayasu Egawa, Qian Wang, Heather M. Griffin

  Affiliations Department of Pathology, University of Cambridge, Cambridge, United Kingdom, Francis Crick Institute, Mill Hill Laboratory, The Ridgeway, Mill Hill, London, United Kingdom

  ⨯
• Isao Murakami,

  Affiliations Department of Pathology, University of Cambridge, Cambridge, United Kingdom, Francis Crick Institute, Mill Hill Laboratory, The Ridgeway, Mill Hill, London, United Kingdom

  http://orcid.org/0000-0002-7189-3315

  ⨯
• Deborah Jackson,

  Affiliation Francis Crick Institute, Mill Hill Laboratory, The Ridgeway, Mill Hill, London, United Kingdom

  ⨯
• Radma Mahmood,

  Affiliation Francis Crick Institute, Mill Hill Laboratory, The Ridgeway, Mill Hill, London, United Kingdom

  ⨯
• John Doorbar

  * E-mail: jd121@cam.ac.uk

  Affiliations Department of Pathology, University of Cambridge, Cambridge, United Kingdom, Francis Crick Institute, Mill Hill Laboratory, The Ridgeway, Mill Hill, London, United Kingdom

  http://orcid.org/0000-0002-4027-102X

  ⨯