The E3 ubiquitin ligase RNF185 facilitates the cGAS-mediated innate immune response

Qiang Wang; Liyuan Huang; Ze Hong; Zhongshi Lv; Zhaomin Mao; Yijun Tang; Xiufang Kong; Senlin Li; Ye Cui; Heng Liu; Lele Zhang; Xiaojie Zhang; Lindi Jiang; Chen Wang; Qin Zhou

doi:10.1371/journal.ppat.1006264

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Open Access

Peer-reviewed

Research Article

The E3 ubiquitin ligase RNF185 facilitates the cGAS-mediated innate immune response

Qiang Wang ,

Contributed equally to this work with: Qiang Wang, Liyuan Huang

Affiliations Division of Molecular Nephrology and the Creative Training Center for Undergraduates, the Ministry of Education Key Laboratory of Laboratory Medical Diagnostics, the School of Laboratory Medicine, Chongqing Medical University, Chongqing, China, State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
⨯
Liyuan Huang ,

Contributed equally to this work with: Qiang Wang, Liyuan Huang

Affiliation Division of Molecular Nephrology and the Creative Training Center for Undergraduates, the Ministry of Education Key Laboratory of Laboratory Medical Diagnostics, the School of Laboratory Medicine, Chongqing Medical University, Chongqing, China
⨯
Ze Hong,

Affiliation School of Life Science and Technology, China Pharmaceutical University, Jiangning District, Nanjing, China

http://orcid.org/0000-0001-5132-7335

⨯
Zhongshi Lv,

Affiliation Division of Molecular Nephrology and the Creative Training Center for Undergraduates, the Ministry of Education Key Laboratory of Laboratory Medical Diagnostics, the School of Laboratory Medicine, Chongqing Medical University, Chongqing, China
⨯
Zhaomin Mao,

Affiliation Division of Molecular Nephrology and the Creative Training Center for Undergraduates, the Ministry of Education Key Laboratory of Laboratory Medical Diagnostics, the School of Laboratory Medicine, Chongqing Medical University, Chongqing, China
⨯
Yijun Tang,

Affiliation State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
⨯
Xiufang Kong,

Affiliation Department of Rheumatology, Zhongshan Hospital, Fudan University, Shanghai, China
⨯
Senlin Li,

Affiliation State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
⨯
Ye Cui,

Affiliation State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
⨯
Heng Liu,

Affiliation State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
⨯
Lele Zhang,

Affiliation State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
⨯
Xiaojie Zhang,

Affiliation Department of Rheumatology, Zhongshan Hospital, Fudan University, Shanghai, China
⨯
Lindi Jiang,

Affiliation Department of Rheumatology, Zhongshan Hospital, Fudan University, Shanghai, China
⨯
Chen Wang ,

* E-mail: zhouqin@cqmu.edu.cn (QZ); cwang01@sibcb.ac.cn(CW)

Affiliations State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China, School of Life Science and Technology, China Pharmaceutical University, Jiangning District, Nanjing, China

http://orcid.org/0000-0002-9822-9393

⨯
Qin Zhou

* E-mail: zhouqin@cqmu.edu.cn (QZ); cwang01@sibcb.ac.cn(CW)

Affiliation Division of Molecular Nephrology and the Creative Training Center for Undergraduates, the Ministry of Education Key Laboratory of Laboratory Medical Diagnostics, the School of Laboratory Medicine, Chongqing Medical University, Chongqing, China
⨯

The E3 ubiquitin ligase RNF185 facilitates the cGAS-mediated innate immune response

Qiang Wang,
Liyuan Huang,
Ze Hong,
Zhongshi Lv,
Zhaomin Mao,
Yijun Tang,
Xiufang Kong,
Senlin Li,
Ye Cui,
Heng Liu

Published: March 8, 2017
https://doi.org/10.1371/journal.ppat.1006264

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