Hepatitis C virus infection inhibits a Src-kinase regulatory phosphatase and reduces T cell activation in vivo

Nirjal Bhattarai; James H. McLinden; Jinhua Xiang; M. Meleah Mathahs; Warren N. Schmidt; Thomas M. Kaufman; Jack T. Stapleton

doi:10.1371/journal.ppat.1006232

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Peer-reviewed

Research Article

Hepatitis C virus infection inhibits a Src-kinase regulatory phosphatase and reduces T cell activation in vivo

Nirjal Bhattarai,

Current address: Food and Drug Administration, Center for Biologics Evaluation and Research, Silver Spring, Maryland, United States of America

Affiliations Research and Medical Services, Iowa City Veterans Affairs Medical Center, Iowa City, Iowa, United States of America, The Department of Internal Medicine, University of Iowa, Iowa City, Iowa, United States of America
⨯
James H. McLinden,

Affiliations Research and Medical Services, Iowa City Veterans Affairs Medical Center, Iowa City, Iowa, United States of America, The Department of Internal Medicine, University of Iowa, Iowa City, Iowa, United States of America
⨯
Jinhua Xiang,

Affiliations Research and Medical Services, Iowa City Veterans Affairs Medical Center, Iowa City, Iowa, United States of America, The Department of Internal Medicine, University of Iowa, Iowa City, Iowa, United States of America
⨯
M. Meleah Mathahs,

Affiliations Research and Medical Services, Iowa City Veterans Affairs Medical Center, Iowa City, Iowa, United States of America, The Department of Internal Medicine, University of Iowa, Iowa City, Iowa, United States of America
⨯
Warren N. Schmidt,

Affiliations Research and Medical Services, Iowa City Veterans Affairs Medical Center, Iowa City, Iowa, United States of America, The Department of Internal Medicine, University of Iowa, Iowa City, Iowa, United States of America
⨯
Thomas M. Kaufman,

Affiliations Research and Medical Services, Iowa City Veterans Affairs Medical Center, Iowa City, Iowa, United States of America, The Department of Internal Medicine, University of Iowa, Iowa City, Iowa, United States of America
⨯
Jack T. Stapleton

* E-mail: jack-stapleton@uiowa.edu

Affiliations Research and Medical Services, Iowa City Veterans Affairs Medical Center, Iowa City, Iowa, United States of America, The Department of Internal Medicine, University of Iowa, Iowa City, Iowa, United States of America, The Department of Microbiology, University of Iowa, Iowa City, Iowa, United States of America

http://orcid.org/0000-0002-2302-9055

⨯

Hepatitis C virus infection inhibits a Src-kinase regulatory phosphatase and reduces T cell activation in vivo

Nirjal Bhattarai,
James H. McLinden,
Jinhua Xiang,
M. Meleah Mathahs,
Warren N. Schmidt,
Thomas M. Kaufman,
Jack T. Stapleton

Published: February 24, 2017
https://doi.org/10.1371/journal.ppat.1006232

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Hepatitis C virus
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Complement system
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3' UTR
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T cell receptors
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TCR signaling cascade
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Transfection
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T cells
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