Ex vivo activation of CD4+ T-cells from donors on suppressive ART can lead to sustained production of infectious HIV-1 from a subset of infected cells

John K. Bui; Elias K. Halvas; Elizabeth Fyne; Michele D. Sobolewski; Dianna Koontz; Wei Shao; Brian Luke; Feiyu F. Hong; Mary F. Kearney; John W. Mellors

doi:10.1371/journal.ppat.1006230

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Open Access

Peer-reviewed

Research Article

Ex vivo activation of CD4⁺ T-cells from donors on suppressive ART can lead to sustained production of infectious HIV-1 from a subset of infected cells

John K. Bui,

Affiliations Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, Howard Hughes Medical Research Fellows Program, Howard Hughes Medical Institute, Bethesda, Maryland, United States of America

http://orcid.org/0000-0001-5905-2049

⨯
Elias K. Halvas,

Affiliation Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

http://orcid.org/0000-0002-4890-1209

⨯
Elizabeth Fyne,

Affiliation Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Michele D. Sobolewski,

Affiliation Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Dianna Koontz,

Affiliation Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

http://orcid.org/0000-0001-6744-7657

⨯
Wei Shao,

Affiliation Advanced Biomedical Computing Center, Frederick National Laboratory for Cancer Research operated by Leidos Biomedical Research, Inc., Frederick, Maryland, United States of America
⨯
Brian Luke,

Affiliation Advanced Biomedical Computing Center, Frederick National Laboratory for Cancer Research operated by Leidos Biomedical Research, Inc., Frederick, Maryland, United States of America
⨯
Feiyu F. Hong,

Affiliation Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Mary F. Kearney,

Affiliation HIV Dynamics and Replication Program, National Cancer Institute, Frederick, Maryland, United States of America
⨯
John W. Mellors

* E-mail: jwm1@pitt.edu

Affiliation Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯

Ex vivo activation of CD4⁺ T-cells from donors on suppressive ART can lead to sustained production of infectious HIV-1 from a subset of infected cells

John K. Bui,
Elias K. Halvas,
Elizabeth Fyne,
Michele D. Sobolewski,
Dianna Koontz,
Wei Shao,
Brian Luke,
Feiyu F. Hong,
Mary F. Kearney,
John W. Mellors

Published: February 22, 2017
https://doi.org/10.1371/journal.ppat.1006230

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