OSBPL10, RXRA and lipid metabolism confer African-ancestry protection against dengue haemorrhagic fever in admixed Cubans

• Beatriz Sierra ,

  Contributed equally to this work with: Beatriz Sierra, Petr Triska

  * E-mail: Siebet@ipk.sld.cu (BS); luisap@ipatimup.pt (LP)

  Affiliation Virology Department, PAHO/WHO Collaborating Center for the Study of Dengue and its Vector, Pedro Kourí Institute of Tropical Medicine (IPK),Havana, Cuba

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• Petr Triska ,

  Contributed equally to this work with: Beatriz Sierra, Petr Triska

  Affiliations i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal, Instituto de Patologia e Imunologia Molecular da Universidade do Porto (IPATIMUP), Porto, Portugal, Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Universidade do Porto, Porto, Portugal

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• Pedro Soares,

  Affiliation Instituto de Patologia e Imunologia Molecular da Universidade do Porto (IPATIMUP), Porto, Portugal

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• Gissel Garcia,

  Affiliation Virology Department, PAHO/WHO Collaborating Center for the Study of Dengue and its Vector, Pedro Kourí Institute of Tropical Medicine (IPK),Havana, Cuba

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• Ana B. Perez,

  Affiliation Virology Department, PAHO/WHO Collaborating Center for the Study of Dengue and its Vector, Pedro Kourí Institute of Tropical Medicine (IPK),Havana, Cuba

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• Eglys Aguirre,

  Affiliation Virology Department, PAHO/WHO Collaborating Center for the Study of Dengue and its Vector, Pedro Kourí Institute of Tropical Medicine (IPK),Havana, Cuba

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• Marisa Oliveira,

  Affiliations i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal, Instituto de Patologia e Imunologia Molecular da Universidade do Porto (IPATIMUP), Porto, Portugal, Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Universidade do Porto, Porto, Portugal, Eukaryote Genotyping Platform, Genopole Pasteur Institute, Paris, France, Functional Genetics of Infectious Diseases Unit, Pasteur Institute, Paris, France

  http://orcid.org/0000-0002-3214-0759

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• Bruno Cavadas,

  Affiliations i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal, Instituto de Patologia e Imunologia Molecular da Universidade do Porto (IPATIMUP), Porto, Portugal

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• Béatrice Regnault,

  Affiliation Eukaryote Genotyping Platform, Genopole Pasteur Institute, Paris, France

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• Mayling Alvarez,

  Affiliation Virology Department, PAHO/WHO Collaborating Center for the Study of Dengue and its Vector, Pedro Kourí Institute of Tropical Medicine (IPK),Havana, Cuba

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• Didye Ruiz,

  Affiliation Virology Department, PAHO/WHO Collaborating Center for the Study of Dengue and its Vector, Pedro Kourí Institute of Tropical Medicine (IPK),Havana, Cuba

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• David C. Samuels,

  Affiliation Vanderbilt Genetics Institute, Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, United States of America

  http://orcid.org/0000-0003-3529-7791

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• Anavaj Sakuntabhai,

  Affiliation Functional Genetics of Infectious Diseases Unit, Pasteur Institute, Paris, France

  http://orcid.org/0000-0001-9099-6937

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• Luisa Pereira ,

  * E-mail: Siebet@ipk.sld.cu (BS); luisap@ipatimup.pt (LP)

  Affiliations i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal, Instituto de Patologia e Imunologia Molecular da Universidade do Porto (IPATIMUP), Porto, Portugal, Faculdade de Medicina da Universidade do Porto (FMUP), Porto, Portugal

  http://orcid.org/0000-0002-4271-1527

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• Maria G. Guzman

  Affiliation Virology Department, PAHO/WHO Collaborating Center for the Study of Dengue and its Vector, Pedro Kourí Institute of Tropical Medicine (IPK),Havana, Cuba

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