CD8+ T cell cytotoxicity mediates pathology in the skin by inflammasome activation and IL-1β production

Fernanda O. Novais; Augusto M. Carvalho; Megan L. Clark; Lucas P. Carvalho; Daniel P. Beiting; Igor E. Brodsky; Edgar M. Carvalho; Phillip Scott

doi:10.1371/journal.ppat.1006196

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Peer-reviewed

Research Article

CD8⁺ T cell cytotoxicity mediates pathology in the skin by inflammasome activation and IL-1β production

Fernanda O. Novais,

Affiliation Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Augusto M. Carvalho,

Affiliation Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Bahia, Brazil
⨯
Megan L. Clark,

Affiliation Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Lucas P. Carvalho,

Affiliations Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Bahia, Brazil, Serviço de Imunologia, Complexo Hospitalar Prof. Edgard Santos, Universidade Federal da Bahia, Salvador, Bahia, Brazil, Instituto Nacional de Ciências e Tecnologia-Doenças Tropicais, Salvador, Bahia, Brazil
⨯
Daniel P. Beiting,

Affiliation Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Igor E. Brodsky,

Affiliation Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Edgar M. Carvalho,

Affiliations Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Bahia, Brazil, Serviço de Imunologia, Complexo Hospitalar Prof. Edgard Santos, Universidade Federal da Bahia, Salvador, Bahia, Brazil, Instituto Nacional de Ciências e Tecnologia-Doenças Tropicais, Salvador, Bahia, Brazil
⨯
Phillip Scott

* E-mail: pscott@upenn.edu

Affiliation Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

http://orcid.org/0000-0001-8732-0653

⨯

CD8⁺ T cell cytotoxicity mediates pathology in the skin by inflammasome activation and IL-1β production

Fernanda O. Novais,
Augusto M. Carvalho,
Megan L. Clark,
Lucas P. Carvalho,
Daniel P. Beiting,
Igor E. Brodsky,
Edgar M. Carvalho,
Phillip Scott

Published: February 13, 2017
https://doi.org/10.1371/journal.ppat.1006196

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Cytotoxic T cells
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T cells
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Parasitic diseases
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Lesions
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Inflammasomes
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