Proline Metabolism is Essential for Trypanosoma brucei brucei Survival in the Tsetse Vector

Brian S. Mantilla; Letícia Marchese; Aitor Casas-Sánchez; Naomi A. Dyer; Nicholas Ejeh; Marc Biran; Frédéric Bringaud; Michael J. Lehane; Alvaro Acosta-Serrano; Ariel M. Silber

doi:10.1371/journal.ppat.1006158

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Peer-reviewed

Research Article

Proline Metabolism is Essential for Trypanosoma brucei brucei Survival in the Tsetse Vector

Brian S. Mantilla,

Affiliation Laboratory of Biochemistry of Tryps - LaBTryps, Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil
⨯
Letícia Marchese,

Affiliation Laboratory of Biochemistry of Tryps - LaBTryps, Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil

http://orcid.org/0000-0002-7688-1188

⨯
Aitor Casas-Sánchez,

Affiliation Department of Parasitology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom

http://orcid.org/0000-0001-5237-1223

⨯
Naomi A. Dyer,

Affiliation Department of Parasitology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom
⨯
Nicholas Ejeh,

Affiliation Department of Parasitology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom

http://orcid.org/0000-0002-6043-4770

⨯
Marc Biran,

Affiliation Centre de Résonance Magnétique des Systemes Biologiques, Université Bordeaux, Bordeaux, France
⨯
Frédéric Bringaud,

Current address: Laboratoire de Microbiologie Fondamentale et Pathogénicité (MFP), Université de Bordeaux, CNRS UMR-5234, Bordeaux, France

Affiliation Centre de Résonance Magnétique des Systemes Biologiques, Université Bordeaux, Bordeaux, France
⨯
Michael J. Lehane,

Affiliation Department of Vector Biology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom
⨯
Alvaro Acosta-Serrano ,

* E-mail: asilber@usp.br (AMS); alvaro.acosta-serrano@lstmed.ac.uk (AAS)

Affiliations Department of Parasitology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom, Department of Vector Biology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom
⨯
Ariel M. Silber

* E-mail: asilber@usp.br (AMS); alvaro.acosta-serrano@lstmed.ac.uk (AAS)

Affiliation Laboratory of Biochemistry of Tryps - LaBTryps, Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil

http://orcid.org/0000-0003-4528-4732

⨯

Proline Metabolism is Essential for Trypanosoma brucei brucei Survival in the Tsetse Vector

Brian S. Mantilla,
Letícia Marchese,
Aitor Casas-Sánchez,
Naomi A. Dyer,
Nicholas Ejeh,
Marc Biran,
Frédéric Bringaud,
Michael J. Lehane,
Alvaro Acosta-Serrano,
Ariel M. Silber

Published: January 23, 2017
https://doi.org/10.1371/journal.ppat.1006158

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