An HSV-2 Trivalent Vaccine Is Immunogenic in Rhesus Macaques and Highly Efficacious in Guinea Pigs

Sita Awasthi; Lauren M. Hook; Carolyn E. Shaw; Bapi Pahar; Jacob A. Stagray; David Liu; Ronald S. Veazey; Harvey M. Friedman

doi:10.1371/journal.ppat.1006141

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Open Access

Peer-reviewed

Research Article

An HSV-2 Trivalent Vaccine Is Immunogenic in Rhesus Macaques and Highly Efficacious in Guinea Pigs

Sita Awasthi,

Affiliation Infectious Disease Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

http://orcid.org/0000-0001-8230-3635

⨯
Lauren M. Hook,

Affiliation Infectious Disease Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Carolyn E. Shaw,

Affiliation Infectious Disease Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Bapi Pahar,

Affiliation Division of Comparative Pathology, Tulane National Primate Research Center, Covington, Louisiana, United States of America
⨯
Jacob A. Stagray,

Current Address: Los Angeles, California, United States of America

Affiliation Division of Comparative Pathology, Tulane National Primate Research Center, Covington, Louisiana, United States of America

http://orcid.org/0000-0002-1764-1096

⨯
David Liu,

Current Address: NIAID IRF, Division of Clinical Research, 8200 Research Plaza, Fort Detrick, Maryland 21702

Affiliation Division of Comparative Pathology, Tulane National Primate Research Center, Covington, Louisiana, United States of America
⨯
Ronald S. Veazey,

Affiliation Division of Comparative Pathology, Tulane National Primate Research Center, Covington, Louisiana, United States of America
⨯
Harvey M. Friedman

* E-mail: hfriedma@mail.med.upenn.edu

Affiliation Infectious Disease Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

http://orcid.org/0000-0002-0765-9460

⨯

An HSV-2 Trivalent Vaccine Is Immunogenic in Rhesus Macaques and Highly Efficacious in Guinea Pigs

Sita Awasthi,
Lauren M. Hook,
Carolyn E. Shaw,
Bapi Pahar,
Jacob A. Stagray,
David Liu,
Ronald S. Veazey,
Harvey M. Friedman

Published: January 19, 2017
https://doi.org/10.1371/journal.ppat.1006141

Reader Comments (5)

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2 Responses

24 Aug 2017
16:58 GMT
Most Recent

Hoping for clinical trials soon. Posted by CureHSV on 26 Feb 2017 at 00:36 GMT
1 Response

26 Jul 2017
16:25 GMT
Most Recent

therapeutic vaccine?? Posted by ccaf on 23 Jul 2017 at 23:30 GMT

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