Blocking two-component signalling enhances Candida albicans virulence and reveals adaptive mechanisms that counteract sustained SAPK activation

Alison M. Day; Deborah A. Smith; Mélanie A. C. Ikeh; Mohammed Haider; Carmen M. Herrero-de-Dios; Alistair J. P. Brown; Brian A. Morgan; Lars P. Erwig; Donna M. MacCallum; Janet Quinn

doi:10.1371/journal.ppat.1006131

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Open Access

Peer-reviewed

Research Article

Blocking two-component signalling enhances Candida albicans virulence and reveals adaptive mechanisms that counteract sustained SAPK activation

Alison M. Day ,

Contributed equally to this work with: Alison M. Day, Deborah A. Smith

Affiliation Institute for Cell and Molecular Biosciences, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯
Deborah A. Smith ,

Contributed equally to this work with: Alison M. Day, Deborah A. Smith

Affiliation Institute for Cell and Molecular Biosciences, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯
Mélanie A. C. Ikeh,

Affiliation Institute for Cell and Molecular Biosciences, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯
Mohammed Haider,

Affiliation Aberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom
⨯
Carmen M. Herrero-de-Dios,

Affiliation Aberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom

http://orcid.org/0000-0002-2042-8480

⨯
Alistair J. P. Brown,

Affiliation Aberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom
⨯
Brian A. Morgan,

Affiliation Institute for Cell and Molecular Biosciences, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯
Lars P. Erwig,

Affiliation Aberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom
⨯
Donna M. MacCallum,

Affiliation Aberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom

http://orcid.org/0000-0003-4833-0378

⨯
Janet Quinn

* E-mail: janet.quinn@ncl.ac.uk

Affiliation Institute for Cell and Molecular Biosciences, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯

Blocking two-component signalling enhances Candida albicans virulence and reveals adaptive mechanisms that counteract sustained SAPK activation

Alison M. Day,
Deborah A. Smith,
Mélanie A. C. Ikeh,
Mohammed Haider,
Carmen M. Herrero-de-Dios,
Alistair J. P. Brown,
Brian A. Morgan,
Lars P. Erwig,
Donna M. MacCallum,
Janet Quinn

Published: January 30, 2017
https://doi.org/10.1371/journal.ppat.1006131

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