Leishmania HASP and SHERP Genes Are Required for In Vivo Differentiation, Parasite Transmission and Virulence Attenuation in the Host

Johannes S. P. Doehl; Jovana Sádlová; Hamide Aslan; Kateřina Pružinová; Sonia Metangmo; Jan Votýpka; Shaden Kamhawi; Petr Volf; Deborah F. Smith

doi:10.1371/journal.ppat.1006130

Loading metrics

Open Access

Peer-reviewed

Research Article

Leishmania HASP and SHERP Genes Are Required for In Vivo Differentiation, Parasite Transmission and Virulence Attenuation in the Host

Johannes S. P. Doehl,

Affiliation Centre for Immunology and Infection, Department of Biology, University of York, York, United Kingdom
⨯
Jovana Sádlová,

Affiliation Department of Parasitology, Faculty of Science, Charles University, Prague, Czech Republic
⨯
Hamide Aslan,

Affiliation Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America
⨯
Kateřina Pružinová,

Affiliation Department of Parasitology, Faculty of Science, Charles University, Prague, Czech Republic
⨯
Sonia Metangmo,

Affiliation Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America

http://orcid.org/0000-0002-5210-6857

⨯
Jan Votýpka,

Affiliation Department of Parasitology, Faculty of Science, Charles University, Prague, Czech Republic
⨯
Shaden Kamhawi,

Affiliation Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America
⨯
Petr Volf,

Affiliation Department of Parasitology, Faculty of Science, Charles University, Prague, Czech Republic
⨯
Deborah F. Smith

* E-mail: deborah.smith@york.ac.uk

Affiliation Centre for Immunology and Infection, Department of Biology, University of York, York, United Kingdom
⨯

Leishmania HASP and SHERP Genes Are Required for In Vivo Differentiation, Parasite Transmission and Virulence Attenuation in the Host

Johannes S. P. Doehl,
Jovana Sádlová,
Hamide Aslan,
Kateřina Pružinová,
Sonia Metangmo,
Jan Votýpka,
Shaden Kamhawi,
Petr Volf,
Deborah F. Smith

Published: January 17, 2017
https://doi.org/10.1371/journal.ppat.1006130

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Parasitic diseases
Is the Subject Area "Parasitic diseases" applicable to this article?

Thanks for your feedback.
Sand flies
Is the Subject Area "Sand flies" applicable to this article?

Thanks for your feedback.
Cloning
Is the Subject Area "Cloning" applicable to this article?

Thanks for your feedback.
Genetic loci
Is the Subject Area "Genetic loci" applicable to this article?

Thanks for your feedback.
Leishmania
Is the Subject Area "Leishmania" applicable to this article?

Thanks for your feedback.
Promastigotes
Is the Subject Area "Promastigotes" applicable to this article?

Thanks for your feedback.
Amastigotes
Is the Subject Area "Amastigotes" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.