Experimental Estimation of the Effects of All Amino-Acid Mutations to HIV’s Envelope Protein on Viral Replication in Cell Culture

Open Access

Peer-reviewed

Research Article

Hugh K. Haddox,

Affiliations Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Molecular and Cellular Biology PhD Program, University of Washington, Seattle, Washington, United States of America
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Adam S. Dingens,

Affiliations Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Molecular and Cellular Biology PhD Program, University of Washington, Seattle, Washington, United States of America
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Jesse D. Bloom

* E-mail: jbloom@fredhutch.org

Affiliation Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

http://orcid.org/0000-0003-1267-3408

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Viral replication
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Microbial mutation
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HIV
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Mutation detection
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Cell cultures
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Polymerase chain reaction
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Sequence alignment
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Viral evolution
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