Autophagy Is an Innate Mechanism Associated with Leprosy Polarization

Bruno Jorge de Andrade Silva; Mayara Garcia de Mattos Barbosa; Priscila Ribeiro Andrade; Helen Ferreira; José Augusto da Costa Nery; Suzana Côrte-Real; Gilberto Marcelo Sperandio da Silva; Patricia Sammarco Rosa; Mario Fabri; Euzenir Nunes Sarno; Roberta Olmo Pinheiro

doi:10.1371/journal.ppat.1006103

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Open Access

Peer-reviewed

Research Article

Autophagy Is an Innate Mechanism Associated with Leprosy Polarization

Bruno Jorge de Andrade Silva ,

Contributed equally to this work with: Bruno Jorge de Andrade Silva, Mayara Garcia de Mattos Barbosa

Affiliation Leprosy Laboratory; Oswaldo Cruz Institute; Oswaldo Cruz Foundation, FIOCRUZ; Rio de Janeiro, Brazil
⨯
Mayara Garcia de Mattos Barbosa ,

Contributed equally to this work with: Bruno Jorge de Andrade Silva, Mayara Garcia de Mattos Barbosa

Affiliation Leprosy Laboratory; Oswaldo Cruz Institute; Oswaldo Cruz Foundation, FIOCRUZ; Rio de Janeiro, Brazil
⨯
Priscila Ribeiro Andrade,

Affiliation Leprosy Laboratory; Oswaldo Cruz Institute; Oswaldo Cruz Foundation, FIOCRUZ; Rio de Janeiro, Brazil
⨯
Helen Ferreira,

Affiliation Leprosy Laboratory; Oswaldo Cruz Institute; Oswaldo Cruz Foundation, FIOCRUZ; Rio de Janeiro, Brazil
⨯
José Augusto da Costa Nery,

Affiliation Leprosy Laboratory; Oswaldo Cruz Institute; Oswaldo Cruz Foundation, FIOCRUZ; Rio de Janeiro, Brazil
⨯
Suzana Côrte-Real,

Affiliation Structural Biology Laboratory; Oswaldo Cruz Institute; Oswaldo Cruz Foundation, FIOCRUZ; Rio de Janeiro, Brazil
⨯
Gilberto Marcelo Sperandio da Silva,

Affiliation Evandro Chagas National Institute of Infectology; FIOCRUZ; Rio de Janeiro, Brazil
⨯
Patricia Sammarco Rosa,

Affiliation Laboratory Animal House; Lauro de Souza Lima Institute; São Paulo, Brazil
⨯
Mario Fabri,

Affiliations Department of Dermatology; University of Cologne; Cologne, Germany, Center for Molecular Medicine; University of Cologne; Cologne, Germany
⨯
Euzenir Nunes Sarno,

Affiliation Leprosy Laboratory; Oswaldo Cruz Institute; Oswaldo Cruz Foundation, FIOCRUZ; Rio de Janeiro, Brazil
⨯
Roberta Olmo Pinheiro

* E-mail: rolmo@ioc.fiocruz.br

Affiliation Leprosy Laboratory; Oswaldo Cruz Institute; Oswaldo Cruz Foundation, FIOCRUZ; Rio de Janeiro, Brazil

http://orcid.org/0000-0001-8471-4227

⨯

Autophagy Is an Innate Mechanism Associated with Leprosy Polarization

Bruno Jorge de Andrade Silva,
Mayara Garcia de Mattos Barbosa,
Priscila Ribeiro Andrade,
Helen Ferreira,
José Augusto da Costa Nery,
Suzana Côrte-Real,
Gilberto Marcelo Sperandio da Silva,
Patricia Sammarco Rosa,
Mario Fabri,
Euzenir Nunes Sarno

Published: January 5, 2017
https://doi.org/10.1371/journal.ppat.1006103

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Autophagic cell death
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Lesions
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Mycobacterium leprae
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Leprosy
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Gene expression
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Lysosomes
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Monocytes
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Macrophages
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