Integrated Activity and Genetic Profiling of Secreted Peptidases in Cryptococcus neoformans Reveals an Aspartyl Peptidase Required for Low pH Survival and Virulence

• Starlynn C. Clarke,

  Affiliation Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California, United States of America

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• Phillip A. Dumesic,

  Affiliation Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, United States of America

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• Christina M. Homer,

  Affiliation Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, United States of America

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• Anthony J. O’Donoghue,

  Current address: Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California, United States of America

  Affiliation Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California, United States of America

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• Florencia La Greca,

  Affiliation Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California, United States of America

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• Lenka Pallova,

  Affiliation Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic

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• Pavel Majer,

  Affiliation Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic

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• Hiten D. Madhani ,

  * E-mail: Charles.Craik@UCSF.edu (CSC); HitenMadhani@gmail.com (HDM)

  Affiliation Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, United States of America

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• Charles S. Craik

  * E-mail: Charles.Craik@UCSF.edu (CSC); HitenMadhani@gmail.com (HDM)

  Affiliation Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California, United States of America

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