Trehalose-6-Phosphate-Mediated Toxicity Determines Essentiality of OtsB2 in Mycobacterium tuberculosis In Vitro and in Mice

• Jan Korte ,

  Contributed equally to this work with: Jan Korte, Marina Alber

  Affiliations Institute for Pharmaceutical Biology and Biotechnology, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany, Institute for Medical Microbiology and Hospital Hygiene, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany

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• Marina Alber ,

  Contributed equally to this work with: Jan Korte, Marina Alber

  Affiliation Institute for Medical Microbiology and Hospital Hygiene, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany

  http://orcid.org/0000-0003-1377-0998

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• Carolina M. Trujillo,

  Affiliation Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, United States of America

  http://orcid.org/0000-0002-9601-820X

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• Karl Syson,

  Affiliation Department of Biological Chemistry, John Innes Centre, Norwich Research Park, Norwich, Norfolk, United Kingdom

  http://orcid.org/0000-0002-9624-7221

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• Hendrik Koliwer-Brandl,

  Affiliation Institute for Medical Microbiology and Hospital Hygiene, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany

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• René Deenen,

  Affiliation Biological and Medical Research Center (BMFZ), Cluster of Excellence on Plant Sciences (CEPLAS), Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany

  http://orcid.org/0000-0003-4520-3023

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• Karl Köhrer,

  Affiliation Biological and Medical Research Center (BMFZ), Cluster of Excellence on Plant Sciences (CEPLAS), Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany

  http://orcid.org/0000-0003-3644-2022

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• Michael A. DeJesus,

  Affiliation Department of Computer Science, Texas A&M University, College Station, Texas, United States of America

  http://orcid.org/0000-0003-3867-0299

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• Travis Hartman,

  Current address: Department of Medicine, Weill Cornell Medical College, New York, New York, United States of America

  Affiliation Department of Microbiology and Immunology, Howard Hughes Medical Institute, Albert Einstein College of Medicine, Bronx, New York, United States of America

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• William R. Jacobs Jr.,

  Affiliation Department of Microbiology and Immunology, Howard Hughes Medical Institute, Albert Einstein College of Medicine, Bronx, New York, United States of America

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• Stephen Bornemann,

  Affiliation Department of Biological Chemistry, John Innes Centre, Norwich Research Park, Norwich, Norfolk, United Kingdom

  http://orcid.org/0000-0001-5930-9473

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• Thomas R. Ioerger,

  Affiliation Department of Computer Science, Texas A&M University, College Station, Texas, United States of America

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• Sabine Ehrt,

  Affiliation Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, United States of America

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• Rainer Kalscheuer

  * E-mail: rainer.kalscheuer@uni-duesseldorf.de

  Affiliations Institute for Pharmaceutical Biology and Biotechnology, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany, Institute for Medical Microbiology and Hospital Hygiene, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany

  http://orcid.org/0000-0002-3378-2067

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